Interventions to reduce rehospitalizations after chronic obstructive pulmonary disease exacerbations: A systematic review

Valentin Prieto-Centurion, Michael A. Markos, Norma I. Ramey, Hélène A. Gussin, Sharmilee M. Nyenhuis, Min J. Joo, Bharati Prasad, Nina Bracken, Robert DiDomenico, Patrick O. Godwin, Howard A. Jaffe, Ravi Kalhan, Alan S. Pickard, Barry R. Pittendrigh, Bruce Schatz, Jamie L. Sullivan, Byron M. Thomashow, Mark V. Williams, Jerry A. Krishnan

Research output: Contribution to journalReview article

Abstract

Rationale: Approximately 20% of patients hospitalized for COPD exacerbations in the United States will be readmitted within 30 days. The Centers for Medicare and Medicaid Services has recently proposed to revise the Hospital Readmissions Reduction Program to financially penalize hospitals with high all-cause 30-day rehospitalization rates after a hospitalization for COPD exacerbation on or after October 1, 2014. Objectives: To report the results of a systematic review of randomized clinical trials evaluating interventions to reduce the rehospitalizations after COPD exacerbations. Methods: Multiple electronic databases were systematically searched to identify relevant studies published between January 1966 and June 2013. Titles, abstracts, and, subsequently, full-text articles were assessed for eligibility. Each study was appraised using predefined criteria. Measurements and Main Results: Among 913 titles and abstracts screened, 5 studies (1,393 participants)met eligibility criteria. All studies had a primary outcome of rehospitalization at 6 or 12 months.No study examined 30-day rehospitalization as the primary outcome. Each study tested a different set of interventions. Two studies (one conducted inCanada and one conducted in Spain and Belgium) showed a decrease in all-cause rehospitalization over 12 months in the intervention group versus comparator group (mean number of hospitalizations per patient, 1.0 vs. 1.8; P = 0.01; percent hospitalized, 45 vs. 67%; P = 0.028; respectively). The only study conducted in the United States found a greater than twofold higher risk of mortality in the intervention group (17 vs. 7%, P = 0.003) but no significant difference in rehospitalizations. It was unclear which set of interventions was effective or harmful. Conclusions: The evidence base is inadequate to recommend specific interventions to reduce rehospitalizations in this population and does not justify penalizing hospitals for high 30-day rehospitalization rates after COPD exacerbations.

Original languageEnglish (US)
Pages (from-to)417-424
Number of pages8
JournalAnnals of the American Thoracic Society
Volume11
Issue number3
DOIs
StatePublished - Mar 2014

Fingerprint

Chronic Obstructive Pulmonary Disease
Disease Progression
Hospitalization
Centers for Medicare and Medicaid Services (U.S.)
Patient Readmission
Belgium
Spain
Randomized Controlled Trials
Databases
Mortality
Population

Keywords

  • Chronic obstructive pulmonary disease
  • Rehospitalization
  • Systematic review

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Prieto-Centurion, V., Markos, M. A., Ramey, N. I., Gussin, H. A., Nyenhuis, S. M., Joo, M. J., ... Krishnan, J. A. (2014). Interventions to reduce rehospitalizations after chronic obstructive pulmonary disease exacerbations: A systematic review. Annals of the American Thoracic Society, 11(3), 417-424. https://doi.org/10.1513/AnnalsATS.201308-254OC

Interventions to reduce rehospitalizations after chronic obstructive pulmonary disease exacerbations : A systematic review. / Prieto-Centurion, Valentin; Markos, Michael A.; Ramey, Norma I.; Gussin, Hélène A.; Nyenhuis, Sharmilee M.; Joo, Min J.; Prasad, Bharati; Bracken, Nina; DiDomenico, Robert; Godwin, Patrick O.; Jaffe, Howard A.; Kalhan, Ravi; Pickard, Alan S.; Pittendrigh, Barry R.; Schatz, Bruce; Sullivan, Jamie L.; Thomashow, Byron M.; Williams, Mark V.; Krishnan, Jerry A.

In: Annals of the American Thoracic Society, Vol. 11, No. 3, 03.2014, p. 417-424.

Research output: Contribution to journalReview article

Prieto-Centurion, V, Markos, MA, Ramey, NI, Gussin, HA, Nyenhuis, SM, Joo, MJ, Prasad, B, Bracken, N, DiDomenico, R, Godwin, PO, Jaffe, HA, Kalhan, R, Pickard, AS, Pittendrigh, BR, Schatz, B, Sullivan, JL, Thomashow, BM, Williams, MV & Krishnan, JA 2014, 'Interventions to reduce rehospitalizations after chronic obstructive pulmonary disease exacerbations: A systematic review', Annals of the American Thoracic Society, vol. 11, no. 3, pp. 417-424. https://doi.org/10.1513/AnnalsATS.201308-254OC
Prieto-Centurion, Valentin ; Markos, Michael A. ; Ramey, Norma I. ; Gussin, Hélène A. ; Nyenhuis, Sharmilee M. ; Joo, Min J. ; Prasad, Bharati ; Bracken, Nina ; DiDomenico, Robert ; Godwin, Patrick O. ; Jaffe, Howard A. ; Kalhan, Ravi ; Pickard, Alan S. ; Pittendrigh, Barry R. ; Schatz, Bruce ; Sullivan, Jamie L. ; Thomashow, Byron M. ; Williams, Mark V. ; Krishnan, Jerry A. / Interventions to reduce rehospitalizations after chronic obstructive pulmonary disease exacerbations : A systematic review. In: Annals of the American Thoracic Society. 2014 ; Vol. 11, No. 3. pp. 417-424.
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T2 - A systematic review

AU - Prieto-Centurion, Valentin

AU - Markos, Michael A.

AU - Ramey, Norma I.

AU - Gussin, Hélène A.

AU - Nyenhuis, Sharmilee M.

AU - Joo, Min J.

AU - Prasad, Bharati

AU - Bracken, Nina

AU - DiDomenico, Robert

AU - Godwin, Patrick O.

AU - Jaffe, Howard A.

AU - Kalhan, Ravi

AU - Pickard, Alan S.

AU - Pittendrigh, Barry R.

AU - Schatz, Bruce

AU - Sullivan, Jamie L.

AU - Thomashow, Byron M.

AU - Williams, Mark V.

AU - Krishnan, Jerry A.

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N2 - Rationale: Approximately 20% of patients hospitalized for COPD exacerbations in the United States will be readmitted within 30 days. The Centers for Medicare and Medicaid Services has recently proposed to revise the Hospital Readmissions Reduction Program to financially penalize hospitals with high all-cause 30-day rehospitalization rates after a hospitalization for COPD exacerbation on or after October 1, 2014. Objectives: To report the results of a systematic review of randomized clinical trials evaluating interventions to reduce the rehospitalizations after COPD exacerbations. Methods: Multiple electronic databases were systematically searched to identify relevant studies published between January 1966 and June 2013. Titles, abstracts, and, subsequently, full-text articles were assessed for eligibility. Each study was appraised using predefined criteria. Measurements and Main Results: Among 913 titles and abstracts screened, 5 studies (1,393 participants)met eligibility criteria. All studies had a primary outcome of rehospitalization at 6 or 12 months.No study examined 30-day rehospitalization as the primary outcome. Each study tested a different set of interventions. Two studies (one conducted inCanada and one conducted in Spain and Belgium) showed a decrease in all-cause rehospitalization over 12 months in the intervention group versus comparator group (mean number of hospitalizations per patient, 1.0 vs. 1.8; P = 0.01; percent hospitalized, 45 vs. 67%; P = 0.028; respectively). The only study conducted in the United States found a greater than twofold higher risk of mortality in the intervention group (17 vs. 7%, P = 0.003) but no significant difference in rehospitalizations. It was unclear which set of interventions was effective or harmful. Conclusions: The evidence base is inadequate to recommend specific interventions to reduce rehospitalizations in this population and does not justify penalizing hospitals for high 30-day rehospitalization rates after COPD exacerbations.

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