Intervention modalities for targeting cognitive-motor interference in individuals with neurodegenerative disease: a systematic review

Douglas A. Wajda, Anat Mirelman, Jeffrey M. Hausdorff, Jacob J Sosnoff

Research output: Contribution to journalReview article

Abstract

Introduction: Individuals with neurodegenerative disease (NDD) commonly have elevated cognitive-motor interference, change in either cognitive or motor performance (or both) when tasks are performed simultaneously, compared to healthy controls. Given that cognitive-motor interference is related to reduced community ambulation and elevated fall risk, it is a target of rehabilitation interventions. Areas covered: This review details the collective findings of previous dual task interventions in individuals with NDD. A total of 21 investigations focusing on 4 different neurodegenerative diseases and one NDD precursor (Parkinson’s disease, multiple sclerosis, Alzheimer’s disease (AD), dementia other than AD, and mild cognitive impairment) consisting of 721 participants were reviewed. Expert commentary: Preliminary evidence from interventions targeting cognitive-motor interference, both directly and indirectly, show promising results for improving CMI in individuals with neurodegenerative diseases. Methodological limitations, common to pilot investigations preclude firm conclusions. Well-designed randomized control trials targeting cognitive motor interference are warranted.

Original languageEnglish (US)
Pages (from-to)251-261
Number of pages11
JournalExpert Review of Neurotherapeutics
Volume17
Issue number3
DOIs
StatePublished - Mar 4 2017

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Neurodegenerative Diseases
Alzheimer Disease
Multiple Sclerosis
Walking
Parkinson Disease
Rehabilitation

Keywords

  • Dual task
  • cognitive-motor
  • neurodegenerative disease
  • training
  • virtual reality

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Intervention modalities for targeting cognitive-motor interference in individuals with neurodegenerative disease : a systematic review. / Wajda, Douglas A.; Mirelman, Anat; Hausdorff, Jeffrey M.; Sosnoff, Jacob J.

In: Expert Review of Neurotherapeutics, Vol. 17, No. 3, 04.03.2017, p. 251-261.

Research output: Contribution to journalReview article

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