Interval mapping of growth in divergent swine cross

A. Albert Paszek; Patricia J. Wilkie; Gail H. Flickinger; Gary A. Rohrer; Leeson J. Alexander; Craig W. Beattie; Lawrence B. Schook

doi:10.1007/s003359900955

Interval mapping of growth in divergent swine cross

A. Albert Paszek, Patricia J. Wilkie, Gail H. Flickinger, Gary A. Rohrer, Leeson J. Alexander, Craig W. Beattie, Lawrence B. Schook

Research output: Contribution to journal › Article › peer-review

Abstract

A genomic scan of 18 swine autosomal chromosomes was constructed with 119 polymorphic microsatellite (ms) markers to identify quantitative trait loci (QTL) for 11 growth traits in the University of Illinois Meishan x Yorkshire Swine Resource Family. A significant QTL effect was found for post- weaning average daily gain (ADG) between 5.5 and 56 kg of body weight that mapped between markers SW373 and SW1301 near the telomere of Chromosome (Chr) 1 q (SSC1). This QTL effect had a nominal (pointwise) p-value of 0.000007, a genome wide p-value of 0.012, and accounted for 26% of the F₂ phenotypic variance. The same chromosome region also had significant effects on ADG between birth and 56 kg body weight (p-value = .000227), and on ADG between 35 and 56 kg (p-value= .00077). These observations suggest that a significant QTL for post-weaning growth resides on SSC1.

Original language	English (US)
Pages (from-to)	117-122
Number of pages	6
Journal	Mammalian Genome
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s003359900955
State	Published - 1999
Externally published	Yes

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Genetics

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10.1007/s003359900955

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title = "Interval mapping of growth in divergent swine cross",

abstract = "A genomic scan of 18 swine autosomal chromosomes was constructed with 119 polymorphic microsatellite (ms) markers to identify quantitative trait loci (QTL) for 11 growth traits in the University of Illinois Meishan x Yorkshire Swine Resource Family. A significant QTL effect was found for post- weaning average daily gain (ADG) between 5.5 and 56 kg of body weight that mapped between markers SW373 and SW1301 near the telomere of Chromosome (Chr) 1 q (SSC1). This QTL effect had a nominal (pointwise) p-value of 0.000007, a genome wide p-value of 0.012, and accounted for 26% of the F2 phenotypic variance. The same chromosome region also had significant effects on ADG between birth and 56 kg body weight (p-value = .000227), and on ADG between 35 and 56 kg (p-value= .00077). These observations suggest that a significant QTL for post-weaning growth resides on SSC1.",

author = "Paszek, {A. Albert} and Wilkie, {Patricia J.} and Flickinger, {Gail H.} and Rohrer, {Gary A.} and Alexander, {Leeson J.} and Beattie, {Craig W.} and Schook, {Lawrence B.}",

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T1 - Interval mapping of growth in divergent swine cross

AU - Paszek, A. Albert

AU - Wilkie, Patricia J.

AU - Flickinger, Gail H.

AU - Rohrer, Gary A.

AU - Alexander, Leeson J.

AU - Beattie, Craig W.

AU - Schook, Lawrence B.

PY - 1999

Y1 - 1999

N2 - A genomic scan of 18 swine autosomal chromosomes was constructed with 119 polymorphic microsatellite (ms) markers to identify quantitative trait loci (QTL) for 11 growth traits in the University of Illinois Meishan x Yorkshire Swine Resource Family. A significant QTL effect was found for post- weaning average daily gain (ADG) between 5.5 and 56 kg of body weight that mapped between markers SW373 and SW1301 near the telomere of Chromosome (Chr) 1 q (SSC1). This QTL effect had a nominal (pointwise) p-value of 0.000007, a genome wide p-value of 0.012, and accounted for 26% of the F2 phenotypic variance. The same chromosome region also had significant effects on ADG between birth and 56 kg body weight (p-value = .000227), and on ADG between 35 and 56 kg (p-value= .00077). These observations suggest that a significant QTL for post-weaning growth resides on SSC1.

AB - A genomic scan of 18 swine autosomal chromosomes was constructed with 119 polymorphic microsatellite (ms) markers to identify quantitative trait loci (QTL) for 11 growth traits in the University of Illinois Meishan x Yorkshire Swine Resource Family. A significant QTL effect was found for post- weaning average daily gain (ADG) between 5.5 and 56 kg of body weight that mapped between markers SW373 and SW1301 near the telomere of Chromosome (Chr) 1 q (SSC1). This QTL effect had a nominal (pointwise) p-value of 0.000007, a genome wide p-value of 0.012, and accounted for 26% of the F2 phenotypic variance. The same chromosome region also had significant effects on ADG between birth and 56 kg body weight (p-value = .000227), and on ADG between 35 and 56 kg (p-value= .00077). These observations suggest that a significant QTL for post-weaning growth resides on SSC1.

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Interval mapping of growth in divergent swine cross

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