Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

Pin Chieh Huang; Eric J. Chaney; Rishyashring R. Iyer; Darold R. Spillman; Boris Odintsov; Nahil A. Sobh; Stephen A. Boppart

doi:10.1364/BOE.10.000539

Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

Pin Chieh Huang, Eric J. Chaney, Rishyashring R. Iyer, Darold R. Spillman, Boris Odintsov, Nahil A. Sobh, Stephen A. Boppart

Research output: Contribution to journal › Article

Abstract

While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.

Original language	English (US)
Pages (from-to)	539-551
Number of pages	13
Journal	Biomedical Optics Express
Volume	10
Issue number	2
DOIs	https://doi.org/10.1364/BOE.10.000539
State	Published - Jan 1 2019

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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Huang, P. C., Chaney, E. J., Iyer, R. R., Spillman, D. R., Odintsov, B., Sobh, N. A., & Boppart, S. A. (2019). Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography. Biomedical Optics Express, 10(2), 539-551. https://doi.org/10.1364/BOE.10.000539

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abstract = "While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be {\textquoteleft}theranostically{\textquoteright} probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.",

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AU - Odintsov, Boris

AU - Sobh, Nahil A.

AU - Boppart, Stephen A.

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