Abstract
While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 539-551 |
| Number of pages | 13 |
| Journal | Biomedical Optics Express |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2019 |
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ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics
Cite this
Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography. / Huang, Pin Chieh; Chaney, Eric J.; Iyer, Rishyashring R.; Spillman, Darold R.; Odintsov, Boris; Sobh, Nahil A.; Boppart, Stephen Allen.
In: Biomedical Optics Express, Vol. 10, No. 2, 01.01.2019, p. 539-551.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography
AU - Huang, Pin Chieh
AU - Chaney, Eric J.
AU - Iyer, Rishyashring R.
AU - Spillman, Darold R.
AU - Odintsov, Boris
AU - Sobh, Nahil A.
AU - Boppart, Stephen Allen
PY - 2019/1/1
Y1 - 2019/1/1
N2 - While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.
AB - While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.
UR - http://www.scopus.com/inward/record.url?scp=85061523602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061523602&partnerID=8YFLogxK
U2 - 10.1364/BOE.10.000539
DO - 10.1364/BOE.10.000539
M3 - Article
AN - SCOPUS:85061523602
VL - 10
SP - 539
EP - 551
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 2
ER -