@article{13c40c94bb904db6853a1cd1ee1dd74b,
title = "Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography",
abstract = "While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be {\textquoteleft}theranostically{\textquoteright} probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.",
author = "Huang, {Pin Chieh} and Chaney, {Eric J.} and Iyer, {Rishyashring R.} and Spillman, {Darold R.} and Boris Odintsov and Sobh, {Nahil A.} and Boppart, {Stephen A.}",
note = "Funding Information: National Institute of Health (NCI, R01CA213149; NIBIB, R01EB013723). Acknowledgements P.-C. Huang would like to acknowledge the Government Scholarship to Study Abroad (GSSA) from the Ministry of Education, Taiwan. The authors would like to thank Dr. Christina Cocca (Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, IL) for providing the excised canine soft tissue sarcoma tissues. The authors would also like to thank Dr. Adeel Ahmad (formerly from the Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, IL) for the helpful discussions at the early stage of this study. Additional information can be found at: http://biophotonics.illinois.edu. Publisher Copyright: {\textcopyright} 2019 Optical Society of America.",
year = "2019",
doi = "10.1364/BOE.10.000539",
language = "English (US)",
volume = "10",
pages = "539--551",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "2",
}