Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

Pin Chieh Huang, Eric J. Chaney, Rishyashring R. Iyer, Darold R. Spillman, Boris Odintsov, Nahil A. Sobh, Stephen Allen Boppart

Research output: Contribution to journalArticle

Abstract

While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.

Original languageEnglish (US)
Pages (from-to)539-551
Number of pages13
JournalBiomedical Optics Express
Volume10
Issue number2
DOIs
StatePublished - Jan 1 2019

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Elasticity Imaging Techniques
Induced Hyperthermia
S waves
dosimeters
interstitials
Hot Temperature
Elasticity
elastic properties
stiffening
histology
indentation
thermal energy
liver
ablation
tumors
cancer
Sarcoma
damage
Canidae
heat

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography. / Huang, Pin Chieh; Chaney, Eric J.; Iyer, Rishyashring R.; Spillman, Darold R.; Odintsov, Boris; Sobh, Nahil A.; Boppart, Stephen Allen.

In: Biomedical Optics Express, Vol. 10, No. 2, 01.01.2019, p. 539-551.

Research output: Contribution to journalArticle

Huang, Pin Chieh ; Chaney, Eric J. ; Iyer, Rishyashring R. ; Spillman, Darold R. ; Odintsov, Boris ; Sobh, Nahil A. ; Boppart, Stephen Allen. / Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography. In: Biomedical Optics Express. 2019 ; Vol. 10, No. 2. pp. 539-551.
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