Abstract
Intermediary metabolism studies have typically concentrated on four major regulatory mechanisms—substrate availability, allosteric enzyme regulation, post-translational enzyme modification, and regulated enzyme synthesis. Although transcriptional control has been a big focus, it is becoming increasingly evident that many post-transcriptional events are deeply embedded within the core regulatory circuits of enzyme synthesis/breakdown that maintain metabolic homeostasis. The prominent post-transcriptional mechanisms affecting intermediary metabolism include alternative pre-mRNA processing, mRNA stability and translation control, and the more recently discovered regulation by noncoding RNAs. In this review, we discuss the latest advances in our understanding of these diverse mechanisms at the cell-, tissue- and organismal-level. We also highlight the dynamics, complexity and non-linear nature of their regulatory roles in metabolic decision making, and deliberate some of the outstanding questions and challenges in this rapidly expanding field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 349-362 |
| Number of pages | 14 |
| Journal | Biochimica et Biophysica Acta - Gene Regulatory Mechanisms |
| Volume | 1860 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2017 |
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Keywords
- Alternative splicing
- LncRNA
- Metabolic syndrome
- MicroRNA
- Post-transcriptional gene regulation
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
Cite this
Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism. / Arif, Waqar; Datar, Gandhar; Kalsotra, Auinash.
In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1860, No. 3, 01.03.2017, p. 349-362.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
AU - Arif, Waqar
AU - Datar, Gandhar
AU - Kalsotra, Auinash
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Intermediary metabolism studies have typically concentrated on four major regulatory mechanisms—substrate availability, allosteric enzyme regulation, post-translational enzyme modification, and regulated enzyme synthesis. Although transcriptional control has been a big focus, it is becoming increasingly evident that many post-transcriptional events are deeply embedded within the core regulatory circuits of enzyme synthesis/breakdown that maintain metabolic homeostasis. The prominent post-transcriptional mechanisms affecting intermediary metabolism include alternative pre-mRNA processing, mRNA stability and translation control, and the more recently discovered regulation by noncoding RNAs. In this review, we discuss the latest advances in our understanding of these diverse mechanisms at the cell-, tissue- and organismal-level. We also highlight the dynamics, complexity and non-linear nature of their regulatory roles in metabolic decision making, and deliberate some of the outstanding questions and challenges in this rapidly expanding field.
AB - Intermediary metabolism studies have typically concentrated on four major regulatory mechanisms—substrate availability, allosteric enzyme regulation, post-translational enzyme modification, and regulated enzyme synthesis. Although transcriptional control has been a big focus, it is becoming increasingly evident that many post-transcriptional events are deeply embedded within the core regulatory circuits of enzyme synthesis/breakdown that maintain metabolic homeostasis. The prominent post-transcriptional mechanisms affecting intermediary metabolism include alternative pre-mRNA processing, mRNA stability and translation control, and the more recently discovered regulation by noncoding RNAs. In this review, we discuss the latest advances in our understanding of these diverse mechanisms at the cell-, tissue- and organismal-level. We also highlight the dynamics, complexity and non-linear nature of their regulatory roles in metabolic decision making, and deliberate some of the outstanding questions and challenges in this rapidly expanding field.
KW - Alternative splicing
KW - LncRNA
KW - Metabolic syndrome
KW - MicroRNA
KW - Post-transcriptional gene regulation
UR - http://www.scopus.com/inward/record.url?scp=85010289876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010289876&partnerID=8YFLogxK
U2 - 10.1016/j.bbagrm.2017.01.004
DO - 10.1016/j.bbagrm.2017.01.004
M3 - Review article
VL - 1860
SP - 349
EP - 362
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
SN - 1874-9399
IS - 3
ER -