Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism

Waqar Arif, Gandhar Datar, Auinash Kalsotra

Research output: Contribution to journalReview article

Abstract

Intermediary metabolism studies have typically concentrated on four major regulatory mechanisms—substrate availability, allosteric enzyme regulation, post-translational enzyme modification, and regulated enzyme synthesis. Although transcriptional control has been a big focus, it is becoming increasingly evident that many post-transcriptional events are deeply embedded within the core regulatory circuits of enzyme synthesis/breakdown that maintain metabolic homeostasis. The prominent post-transcriptional mechanisms affecting intermediary metabolism include alternative pre-mRNA processing, mRNA stability and translation control, and the more recently discovered regulation by noncoding RNAs. In this review, we discuss the latest advances in our understanding of these diverse mechanisms at the cell-, tissue- and organismal-level. We also highlight the dynamics, complexity and non-linear nature of their regulatory roles in metabolic decision making, and deliberate some of the outstanding questions and challenges in this rapidly expanding field.

Original languageEnglish (US)
Pages (from-to)349-362
Number of pages14
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1860
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • Alternative splicing
  • LncRNA
  • Metabolic syndrome
  • MicroRNA
  • Post-transcriptional gene regulation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

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