TY - JOUR
T1 - Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
AU - Arif, Waqar
AU - Datar, Gandhar
AU - Kalsotra, Auinash
N1 - Funding Information:
A.K. is supported by grants from the US National Institutes of Health (R01HL126845), March of Dimes (5-FY14-112), and the Center for Advanced Study at the University of Illinois. W.A. is supported by the US National Institutes of Health pre-doctoral NRSA fellowship (F30DK108567). We thank people in the Kalsotra lab for helpful discussions and comments on the manuscript. We sincerely apologize to colleagues whose work was not discussed in this review because of space constraints.
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Intermediary metabolism studies have typically concentrated on four major regulatory mechanisms—substrate availability, allosteric enzyme regulation, post-translational enzyme modification, and regulated enzyme synthesis. Although transcriptional control has been a big focus, it is becoming increasingly evident that many post-transcriptional events are deeply embedded within the core regulatory circuits of enzyme synthesis/breakdown that maintain metabolic homeostasis. The prominent post-transcriptional mechanisms affecting intermediary metabolism include alternative pre-mRNA processing, mRNA stability and translation control, and the more recently discovered regulation by noncoding RNAs. In this review, we discuss the latest advances in our understanding of these diverse mechanisms at the cell-, tissue- and organismal-level. We also highlight the dynamics, complexity and non-linear nature of their regulatory roles in metabolic decision making, and deliberate some of the outstanding questions and challenges in this rapidly expanding field.
AB - Intermediary metabolism studies have typically concentrated on four major regulatory mechanisms—substrate availability, allosteric enzyme regulation, post-translational enzyme modification, and regulated enzyme synthesis. Although transcriptional control has been a big focus, it is becoming increasingly evident that many post-transcriptional events are deeply embedded within the core regulatory circuits of enzyme synthesis/breakdown that maintain metabolic homeostasis. The prominent post-transcriptional mechanisms affecting intermediary metabolism include alternative pre-mRNA processing, mRNA stability and translation control, and the more recently discovered regulation by noncoding RNAs. In this review, we discuss the latest advances in our understanding of these diverse mechanisms at the cell-, tissue- and organismal-level. We also highlight the dynamics, complexity and non-linear nature of their regulatory roles in metabolic decision making, and deliberate some of the outstanding questions and challenges in this rapidly expanding field.
KW - Alternative splicing
KW - LncRNA
KW - Metabolic syndrome
KW - MicroRNA
KW - Post-transcriptional gene regulation
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U2 - 10.1016/j.bbagrm.2017.01.004
DO - 10.1016/j.bbagrm.2017.01.004
M3 - Review article
C2 - 28088440
AN - SCOPUS:85010289876
SN - 1874-9399
VL - 1860
SP - 349
EP - 362
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 3
ER -