TY - JOUR
T1 - Interphase H1 phosphorylation
T2 - Regulation and functions in chromatin
AU - Liao, Ruiqi
AU - Mizzen, Craig A.
N1 - Funding Information:
The authors gratefully acknowledge funding from the Campus Research Board ( RB15254 ) and the Department of Cell and Developmental Biology of the University of Illinois at Urbana Champaign.
Publisher Copyright:
© 2015 Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Many metazoan cell types differentially express multiple non-allelic amino acid sequence variants of histone H1. Although early work revealed that H1 variants, collectively, are phosphorylated during interphase and mitosis, differences between individual H1 variants in the sites they possess for mitotic and interphase phosphorylation have been elucidated only relatively recently. Here, we review current knowledge on the regulation and function of interphase H1 phosphorylation, with a particular emphasis on how differences in interphase phosphorylation among the H1 variants of mammalian cells may enable them to have differential effects on transcription and other chromatin processes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.
AB - Many metazoan cell types differentially express multiple non-allelic amino acid sequence variants of histone H1. Although early work revealed that H1 variants, collectively, are phosphorylated during interphase and mitosis, differences between individual H1 variants in the sites they possess for mitotic and interphase phosphorylation have been elucidated only relatively recently. Here, we review current knowledge on the regulation and function of interphase H1 phosphorylation, with a particular emphasis on how differences in interphase phosphorylation among the H1 variants of mammalian cells may enable them to have differential effects on transcription and other chromatin processes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.
KW - Cell cycle
KW - Chromatin structure
KW - Epigenetics
KW - Gene regulation
KW - Histone H1
KW - Histone phosphorylation
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U2 - 10.1016/j.bbagrm.2015.11.012
DO - 10.1016/j.bbagrm.2015.11.012
M3 - Article
C2 - 26657617
AN - SCOPUS:84959125086
VL - 1859
SP - 476
EP - 485
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
SN - 1874-9399
IS - 3
ER -