Interphase H1 phosphorylation: Regulation and functions in chromatin

Ruiqi Liao; Craig A. Mizzen

doi:10.1016/j.bbagrm.2015.11.012

Interphase H1 phosphorylation: Regulation and functions in chromatin

Ruiqi Liao, Craig A. Mizzen

Research output: Contribution to journal › Article › peer-review

Abstract

Many metazoan cell types differentially express multiple non-allelic amino acid sequence variants of histone H1. Although early work revealed that H1 variants, collectively, are phosphorylated during interphase and mitosis, differences between individual H1 variants in the sites they possess for mitotic and interphase phosphorylation have been elucidated only relatively recently. Here, we review current knowledge on the regulation and function of interphase H1 phosphorylation, with a particular emphasis on how differences in interphase phosphorylation among the H1 variants of mammalian cells may enable them to have differential effects on transcription and other chromatin processes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.

Original language	English (US)
Pages (from-to)	476-485
Number of pages	10
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1859
Issue number	3
DOIs	https://doi.org/10.1016/j.bbagrm.2015.11.012
State	Published - Mar 1 2016

Keywords

Cell cycle
Chromatin structure
Epigenetics
Gene regulation
Histone H1
Histone phosphorylation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics

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title = "Interphase H1 phosphorylation: Regulation and functions in chromatin",

abstract = "Many metazoan cell types differentially express multiple non-allelic amino acid sequence variants of histone H1. Although early work revealed that H1 variants, collectively, are phosphorylated during interphase and mitosis, differences between individual H1 variants in the sites they possess for mitotic and interphase phosphorylation have been elucidated only relatively recently. Here, we review current knowledge on the regulation and function of interphase H1 phosphorylation, with a particular emphasis on how differences in interphase phosphorylation among the H1 variants of mammalian cells may enable them to have differential effects on transcription and other chromatin processes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan.",

keywords = "Cell cycle, Chromatin structure, Epigenetics, Gene regulation, Histone H1, Histone phosphorylation",

author = "Ruiqi Liao and Mizzen, {Craig A.}",

note = "Funding Information: The authors gratefully acknowledge funding from the Campus Research Board ( RB15254 ) and the Department of Cell and Developmental Biology of the University of Illinois at Urbana Champaign.",

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T2 - Regulation and functions in chromatin

AU - Liao, Ruiqi

AU - Mizzen, Craig A.

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