Abstract
Objective: In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. Design: International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. Results: Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field. The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. Conclusion: Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1624-1632 |
| Number of pages | 9 |
| Journal | Gut |
| Volume | 68 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2019 |
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Keywords
- cancer
- colorectal
- consensus
- microbiome
- oncology
ASJC Scopus subject areas
- Gastroenterology
Cite this
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis. / Scott, Alasdair J.; Alexander, James L.; Merrifield, Claire A.; Cunningham, David; Jobin, Christian; Brown, Robert; Alverdy, John; O'Keefe, Stephen J.; Gaskins, H. Rex; Teare, Julian; Yu, Jun; Hughes, David J.; Verstraelen, Hans; Burton, Jeremy; O'Toole, Paul W.; Rosenberg, Daniel W.; Marchesi, Julian R.; Kinross, James M.
In: Gut, Vol. 68, No. 9, 01.09.2019, p. 1624-1632.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis
AU - Scott, Alasdair J.
AU - Alexander, James L.
AU - Merrifield, Claire A.
AU - Cunningham, David
AU - Jobin, Christian
AU - Brown, Robert
AU - Alverdy, John
AU - O'Keefe, Stephen J.
AU - Gaskins, H. Rex
AU - Teare, Julian
AU - Yu, Jun
AU - Hughes, David J.
AU - Verstraelen, Hans
AU - Burton, Jeremy
AU - O'Toole, Paul W.
AU - Rosenberg, Daniel W.
AU - Marchesi, Julian R.
AU - Kinross, James M.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Objective: In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. Design: International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. Results: Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field. The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. Conclusion: Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
AB - Objective: In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. Design: International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research. Results: Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field. The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis. Conclusion: Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
KW - cancer
KW - colorectal
KW - consensus
KW - microbiome
KW - oncology
UR - http://www.scopus.com/inward/record.url?scp=85065770452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065770452&partnerID=8YFLogxK
U2 - 10.1136/gutjnl-2019-318556
DO - 10.1136/gutjnl-2019-318556
M3 - Article
C2 - 31092590
AN - SCOPUS:85065770452
VL - 68
SP - 1624
EP - 1632
JO - Gut
JF - Gut
SN - 0017-5749
IS - 9
ER -