Interleukin-6 in the aging brain

J. P. Godbout, R. W. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the brain has been suggested to reduce food intake, inhibit memory and learning, cause neurodegeneration, and exacerbate sickness behavior induced by other cytokines. Recent evidence indicates IL-6 levels are increased in brain of healthy aged animals, thus it may play a role in the neurophysiological manifestations of old age. The purpose of this brief report is to discuss the new evidence that suggests an age-related increase in brain IL-6 and the impact this inflammatory cytokine may have on " successful" aging.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalJournal of Neuroimmunology
Volume147
Issue number1-2
DOIs
StatePublished - Feb 2004

Keywords

  • Aging
  • Brain
  • Cytokines
  • Interleukin-6
  • Mice
  • Microglia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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