Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia

William Burgess, Gilles Gheusi, Jianhuayao, Rodney W. Johnson, Robert Dantzer, Keith W. Kelley

Research output: Contribution to journalArticlepeer-review


Interleukin-1β (IL-1β) mediates many of the behavioral responses to infection and inflammation, and IL-1β-converting enzyme (ICE) processes intracellular IL-1β, leading to its maturation and secretion. Here we demonstrate that intracerebroventricular injections of lipopolysaccharide (LPS) produced a greater reduction in both food intake and food-motivated behavior in wild-type compared with ICE-deficient (ICE -/-) mice. This defect occurred although ICE -/- mice were able to fully respond to intracerebroventricular injections of IL-1β. In contrast, ICE -/- mice remained fully responsive to intraperitoneal injections of LPS. These results indicate that brain, but not peripheral, IL-1β plays a critical role in the depression in food intake that occurs during inflammation.

Original languageEnglish (US)
Pages (from-to)R1829-R1833
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number6 43-6
StatePublished - 1998


  • Feeding
  • Lipopolysaccharide

ASJC Scopus subject areas

  • General Medicine


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