Interleaflet diffusion coupling when polymer adsorbs onto one sole leaflet of a supported phospholipid bilayer

Liangfang Zhang, Steve Granick

Research output: Contribution to journalArticlepeer-review

Abstract

Interleaflet diffusion coupling was analyzed when polymer adsorbs onto one sole leaflet of a supported phospholipid bilayer. The surface coverage of QPVP on DLPC bilayers was quantified using Fourier transform infrared spectroscopy in the mode of attenuated total reflection (FTIR-ATR). The lateral diffusion of dye-labeled lipids was measured by fluorescence correlation spectroscopy (FCS) in the two-photon excitation mode using a home-built apparatus. In-plane diffusion within both leaflets of planar-supported DLPC lipid bilayer was measured in the situation where only the outer leaflet contained adsorbed polymer at low surface coverage. The nature of this strong coupling remains speculative and may stem from strong hydrophobic attraction between the two leaflets of the bilayer, from slight interdigitation of lipids between the two bilayer leaflets.

Original languageEnglish (US)
Pages (from-to)1366-1368
Number of pages3
JournalMacromolecules
Volume40
Issue number5
DOIs
StatePublished - Mar 6 2007

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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