Interferometric Synthetic Aperture Microscopy (ISAM)1 is an optical microscopy computed-imaging technique for measuring the optical properties of three-dimensional structures and biological tissues. In this work, the principle of ISAM is reviewed, and its application to imaging tissue properties in various scanning geometries and instrument configurations is explored. The practicality of ISAM is demonstrated by imaging a rat heart and muscle using a real-time implementation of ISAM in conjunction with a clinical cart Optical Coherence Tomography instrument.

Original languageEnglish (US)
Title of host publicationBiomedical Applications of Light Scattering II
StatePublished - 2008
EventBiomedical Applications of Light Scattering II - San Jose, CA, United States
Duration: Jan 19 2008Jan 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherBiomedical Applications of Light Scattering II
Country/TerritoryUnited States
CitySan Jose, CA


  • Inverse scattering
  • Optical coherence tomography

ASJC Scopus subject areas

  • Engineering(all)


Dive into the research topics of 'Interferometric Synthetic Aperture Microscopy: Tissue structure inferred by computed imaging techniques'. Together they form a unique fingerprint.

Cite this