Interferometric synthetic aperture microscopy

Optical coherence tomography (OCT) has grown from a new research tool into a modality with widespread biomedical applications ever since its introduction in the early 1990s [1-5]. OCT is the optical analog of ultrasound imaging, permitting tomographic imaging with micrometer-scale resolution, and with penetration depth of 1-3 mm in biological tissues. e success of OCT can be attributed in large part to the ideal match between imaging technology and the clinical requirements for imaging in the human eye. An excellent early review of the basic methods may be found in Ref. [6]. Within 15 years, OCT became an established imaging modality in ophthalmology [7,8], and to date has made signicant advances toward applications in cardiology [9], dermatology [10], and oncology [11].