Interfacial geometry dictates cancer cell tumorigenicity

Junmin Lee, Amr A. Abdeen, Kathryn L. Wycislo, Timothy M. Fan, Kristopher A. Kilian

Research output: Contribution to journalArticle

Abstract

Within the heterogeneous architecture of tumour tissue there exists an elusive population of stem-like cells that are implicated in both recurrence and metastasis. Here, by using engineered extracellular matrices, we show that geometric features at the perimeter of tumour tissue will prime a population of cells with a stem-cell-like phenotype. These cells show characteristics of cancer stem cells in vitro, as well as enhanced tumorigenicity in murine models of primary tumour growth and pulmonary metastases. We also show that interfacial geometry modulates cell shape, adhesion through integrin α5β1, MAPK and STAT activity, and initiation of pluripotency signalling. Our results for several human cancer cell lines suggest that interfacial geometry triggers a general mechanism for the regulation of cancer-cell state. Similar to how a growing tumour can co-opt normal soluble signalling pathways, our findings demonstrate how cancer can also exploit geometry to orchestrate oncogenesis.

Original languageEnglish (US)
Pages (from-to)856-862
Number of pages7
JournalNature Materials
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2016

Fingerprint

stem cells
Tumors
tumors
cancer
Cells
Geometry
metastasis
geometry
Stem cells
cells
Tissue
phenotype
cultured cells
Integrins
adhesion
Adhesion
actuators
matrices

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M., & Kilian, K. A. (2016). Interfacial geometry dictates cancer cell tumorigenicity. Nature Materials, 15(8), 856-862. https://doi.org/10.1038/nmat4610

Interfacial geometry dictates cancer cell tumorigenicity. / Lee, Junmin; Abdeen, Amr A.; Wycislo, Kathryn L.; Fan, Timothy M.; Kilian, Kristopher A.

In: Nature Materials, Vol. 15, No. 8, 01.08.2016, p. 856-862.

Research output: Contribution to journalArticle

Lee, J, Abdeen, AA, Wycislo, KL, Fan, TM & Kilian, KA 2016, 'Interfacial geometry dictates cancer cell tumorigenicity', Nature Materials, vol. 15, no. 8, pp. 856-862. https://doi.org/10.1038/nmat4610
Lee, Junmin ; Abdeen, Amr A. ; Wycislo, Kathryn L. ; Fan, Timothy M. ; Kilian, Kristopher A. / Interfacial geometry dictates cancer cell tumorigenicity. In: Nature Materials. 2016 ; Vol. 15, No. 8. pp. 856-862.
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