Interaction of mixed ligand copper(II) complexes with CT DNA and BSA: Effect of primary ligand hydrophobicity on DNA and protein binding and cleavage and anticancer activities

Mani Ganeshpandian, Rangasamy Loganathan, Sethu Ramakrishnan, Anvarbatcha Riyasdeen, Mohamad Abdulkadhar Akbarsha, Mallayan Palaniandavar

Research output: Contribution to journalArticlepeer-review

Abstract

A series of mononuclear mixed ligand copper(II) complexes of the type [Cu(pmdt)(diimine)](ClO4)2 1-4, where pmdt is N,N,N′,N″,N″-pentamethyldiethylenetriamine and diimine is 2,2′-bipyridine (1), 1,10-phenanthroline (2), 5,6-dimethyl-1,10- phenanthroline (3) and dipyrido-[3,2-d:2′,3′-f]-quinoxaline (4), have been isolated. All the complexes exhibit square-based pyramidal coordination geometry. The DNA binding affinity (Kb) of the complexes varies as 3 > 4 > 2 > 1 depending on the diimine co-ligand. The complex 3, which strongly binds to both DNA and protein and performs both DNA cleavage and protein cleavage, exhibits a higher cytotoxicity than the other complexes due to enhanced hydrophobicity of both pmdt and the diimine co-ligand. Both 3 and 4 induce cell death through both apoptosis and necrosis and 3 shows more effective ROS generation in cancer cells.

Original languageEnglish (US)
Pages (from-to)924-938
Number of pages15
JournalPolyhedron
Volume52
DOIs
StatePublished - Mar 22 2013
Externally publishedYes

Keywords

  • Anticancer activity
  • BSA protein affinity
  • DNA interaction
  • Hydrophobicity
  • Mixed ligand Cu(II) complexes
  • ROS generation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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