Inter-serotype reassortment among epizootic haemorrhagic disease viruses in the United States

Leyi Wang, Saraswathi Lanka, Debbie Cassout, Nohra E Mateus-Pinilla, Ganwu Li, William C. Wilson, Dongwan Yoo, Paul Shelton, Richard Lincoln Fredrickson

Research output: Contribution to journalArticle

Abstract

First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double-stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year.

Original languageEnglish (US)
JournalTransboundary and Emerging Diseases
DOIs
StatePublished - Jan 1 2019

Fingerprint

Epizootic hemorrhagic disease virus
epizootic hemorrhagic disease
Deer
deer
Disease Outbreaks
serotypes
RNA Viruses
etiological agents
Ruminants
point mutation
Point Mutation
Sequence Analysis
ruminants
Genome
autumn
Viruses
viruses
genome
summer
Infection

Keywords

  • epizootic haemorrhagic disease virus
  • reassortment
  • serotype

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • veterinary(all)

Cite this

Inter-serotype reassortment among epizootic haemorrhagic disease viruses in the United States. / Wang, Leyi; Lanka, Saraswathi; Cassout, Debbie; Mateus-Pinilla, Nohra E; Li, Ganwu; Wilson, William C.; Yoo, Dongwan; Shelton, Paul; Fredrickson, Richard Lincoln.

In: Transboundary and Emerging Diseases, 01.01.2019.

Research output: Contribution to journalArticle

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