Inter-serotype reassortment among epizootic haemorrhagic disease viruses in the United States

Leyi Wang, Saraswathi Lanka, Debbie Cassout, Nohra E. Mateus-Pinilla, Ganwu Li, William C. Wilson, Dongwan Yoo, Paul Shelton, Richard L. Fredrickson

Research output: Contribution to journalArticlepeer-review


First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double-stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year.

Original languageEnglish (US)
Pages (from-to)1809-1820
Number of pages12
JournalTransboundary and Emerging Diseases
Issue number5
StatePublished - Sep 1 2019


  • epizootic haemorrhagic disease virus
  • reassortment
  • serotype
  • United States/epidemiology
  • Animals
  • Reassortant Viruses/genetics
  • Deer/virology
  • Serogroup
  • Phylogeny
  • Disease Outbreaks/veterinary
  • Reoviridae Infections/epidemiology
  • Hemorrhagic Disease Virus, Epizootic/genetics

ASJC Scopus subject areas

  • General Veterinary
  • General Immunology and Microbiology


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