Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PM2.5 mass

Sudheer Salana, Haoran Yu, Zhuying Dai, P. S.Ganesh Subramanian, Joseph V. Puthussery, Yixiang Wang, Ajit Singh, Francis D. Pope, Manuel A. Leiva G, Neeraj Rastogi, Sachchida Nand Tripathi, Rodney J. Weber, Vishal Verma

Research output: Contribution to journalArticlepeer-review

Abstract

Most fine ambient particulate matter (PM2.5)-based epidemiological models use globalized concentration-response (CR) functions assuming that the toxicity of PM2.5 is solely mass-dependent without considering its chemical composition. Although oxidative potential (OP) has emerged as an alternate metric of PM2.5 toxicity, the association between PM2.5 mass and OP on a large spatial extent has not been investigated. In this study, we evaluate this relationship using 385 PM2.5 samples collected from 14 different sites across 4 different continents and using 5 different OP (and cytotoxicity) endpoints. Our results show that the relationship between PM2.5 mass vs. OP (and cytotoxicity) is largely non-linear due to significant differences in the intrinsic toxicity, resulting from a spatially heterogeneous chemical composition of PM2.5. These results emphasize the need to develop localized CR functions incorporating other measures of PM2.5 properties (e.g., OP) to better predict the PM2.5-attributed health burdens.

Original languageEnglish (US)
Article number5263
JournalNature communications
Volume15
Issue number1
DOIs
StatePublished - Dec 2024
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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