TY - JOUR
T1 - Integrin-linked kinase (ILK)
T2 - A regulator of integrin and growth-factor signalling
AU - Dedhar, Shoukat
AU - Williams, Benjamin
AU - Hannigan, Gregory
PY - 1999
Y1 - 1999
N2 - Interaction of cells with the extracellular matrix (ECM) results in the regulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achieve signalling by interacting with intracellular effectors that couple integrins and growth-factor receptors to downstream components. One well- studied effector is focal-adhesion kinase (FAK), but recently another protein kinase, integrin-linked kinase (ILK), has been identified as a receptor- proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling. This article discusses ILK structure and function and recent genetic and biochemical evidence about the role of ILK in signal transduction.
AB - Interaction of cells with the extracellular matrix (ECM) results in the regulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achieve signalling by interacting with intracellular effectors that couple integrins and growth-factor receptors to downstream components. One well- studied effector is focal-adhesion kinase (FAK), but recently another protein kinase, integrin-linked kinase (ILK), has been identified as a receptor- proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling. This article discusses ILK structure and function and recent genetic and biochemical evidence about the role of ILK in signal transduction.
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U2 - 10.1016/S0962-8924(99)01612-8
DO - 10.1016/S0962-8924(99)01612-8
M3 - Review article
C2 - 10407411
AN - SCOPUS:0032787837
VL - 9
SP - 319
EP - 323
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 8
ER -