Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling

Shoukat Dedhar, Benjamin Williams, Gregory Hannigan

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Interaction of cells with the extracellular matrix (ECM) results in the regulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achieve signalling by interacting with intracellular effectors that couple integrins and growth-factor receptors to downstream components. One well- studied effector is focal-adhesion kinase (FAK), but recently another protein kinase, integrin-linked kinase (ILK), has been identified as a receptor- proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling. This article discusses ILK structure and function and recent genetic and biochemical evidence about the role of ILK in signal transduction.

    Original languageEnglish (US)
    Pages (from-to)319-323
    Number of pages5
    JournalTrends in Cell Biology
    Volume9
    Issue number8
    DOIs
    StatePublished - 1999

    ASJC Scopus subject areas

    • Cell Biology

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