Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling

Shoukat Dedhar, Benjamin Williams, Gregory Hannigan

Research output: Contribution to journalReview articlepeer-review

Abstract

Interaction of cells with the extracellular matrix (ECM) results in the regulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achieve signalling by interacting with intracellular effectors that couple integrins and growth-factor receptors to downstream components. One well- studied effector is focal-adhesion kinase (FAK), but recently another protein kinase, integrin-linked kinase (ILK), has been identified as a receptor- proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling. This article discusses ILK structure and function and recent genetic and biochemical evidence about the role of ILK in signal transduction.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalTrends in Cell Biology
Volume9
Issue number8
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Cell Biology

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