Abstract
Using a magnetic twisting cytometry technique, it was shown that integrins directly mediate mechanical stresses across the cell surface and into the cytoskeleton whereas other non-adhesion molecules do not mediate mechanical force transfer across the cell surface. It was also demonstrated that vinculin mechanically couples the integrins with the cytoskeleton. Other cell-cell adhesion molecules such as platelet-endothelial-cell adhesion-molecule-1 (CD31), E-selectin, and E-cadherin were found to mediate mechanical force transfer across the cell surface. Overall, these findings indicate that integrin-cytoskeleton linkages are important pathways for mechanotransduction.
| Original language | English (US) |
|---|---|
| Title of host publication | American Society of Mechanical Engineers, Bioengineering Division (Publication) BED |
| Publisher | ASME |
| Pages | 523-524 |
| Number of pages | 2 |
| Volume | 42 |
| ISBN (Print) | 0791816117 |
| State | Published - 1999 |
| Externally published | Yes |
| Event | 1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999 |
Other
| Other | 1999 Bioengineering Conference |
|---|---|
| City | Big Sky, MT, USA |
| Period | 6/16/99 → 6/20/99 |
ASJC Scopus subject areas
- General Engineering