Abstract
In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 365-370 |
| Number of pages | 6 |
| Journal | Nature |
| Volume | 541 |
| Issue number | 7637 |
| DOIs | |
| State | Published - Jan 19 2017 |
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Integration of temporal and spatial patterning generates neural diversity. / Erclik, Ted; Li, Xin; Courgeon, Maximilien; Bertet, Claire; Chen, Zhenqing; Baumert, Ryan; Ng, June; Koo, Clara; Arain, Urfa; Behnia, Rudy; Del Valle Rodriguez, Alberto; Senderowicz, Lionel; Negre, Nicolas; White, Kevin P.; Desplan, Claude.
In: Nature, Vol. 541, No. 7637, 19.01.2017, p. 365-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Integration of temporal and spatial patterning generates neural diversity
AU - Erclik, Ted
AU - Li, Xin
AU - Courgeon, Maximilien
AU - Bertet, Claire
AU - Chen, Zhenqing
AU - Baumert, Ryan
AU - Ng, June
AU - Koo, Clara
AU - Arain, Urfa
AU - Behnia, Rudy
AU - Del Valle Rodriguez, Alberto
AU - Senderowicz, Lionel
AU - Negre, Nicolas
AU - White, Kevin P.
AU - Desplan, Claude
PY - 2017/1/19
Y1 - 2017/1/19
N2 - In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.
AB - In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.
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UR - http://www.scopus.com/inward/citedby.url?scp=85011074761&partnerID=8YFLogxK
U2 - 10.1038/nature20794
DO - 10.1038/nature20794
M3 - Article
C2 - 28077877
AN - SCOPUS:85011074761
VL - 541
SP - 365
EP - 370
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7637
ER -