Integration of temporal and spatial patterning generates neural diversity

Ted Erclik, Xin Li, Maximilien Courgeon, Claire Bertet, Zhenqing Chen, Ryan Baumert, June Ng, Clara Koo, Urfa Arain, Rudy Behnia, Alberto Del Valle Rodriguez, Lionel Senderowicz, Nicolas Negre, Kevin P. White, Claude Desplan

Research output: Contribution to journalArticle

Abstract

In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalNature
Volume541
Issue number7637
DOIs
StatePublished - Jan 19 2017

Fingerprint

Neurons
Neuropil
Automatic Data Processing
Drosophila

ASJC Scopus subject areas

  • General

Cite this

Erclik, T., Li, X., Courgeon, M., Bertet, C., Chen, Z., Baumert, R., ... Desplan, C. (2017). Integration of temporal and spatial patterning generates neural diversity. Nature, 541(7637), 365-370. https://doi.org/10.1038/nature20794

Integration of temporal and spatial patterning generates neural diversity. / Erclik, Ted; Li, Xin; Courgeon, Maximilien; Bertet, Claire; Chen, Zhenqing; Baumert, Ryan; Ng, June; Koo, Clara; Arain, Urfa; Behnia, Rudy; Del Valle Rodriguez, Alberto; Senderowicz, Lionel; Negre, Nicolas; White, Kevin P.; Desplan, Claude.

In: Nature, Vol. 541, No. 7637, 19.01.2017, p. 365-370.

Research output: Contribution to journalArticle

Erclik, T, Li, X, Courgeon, M, Bertet, C, Chen, Z, Baumert, R, Ng, J, Koo, C, Arain, U, Behnia, R, Del Valle Rodriguez, A, Senderowicz, L, Negre, N, White, KP & Desplan, C 2017, 'Integration of temporal and spatial patterning generates neural diversity', Nature, vol. 541, no. 7637, pp. 365-370. https://doi.org/10.1038/nature20794
Erclik T, Li X, Courgeon M, Bertet C, Chen Z, Baumert R et al. Integration of temporal and spatial patterning generates neural diversity. Nature. 2017 Jan 19;541(7637):365-370. https://doi.org/10.1038/nature20794
Erclik, Ted ; Li, Xin ; Courgeon, Maximilien ; Bertet, Claire ; Chen, Zhenqing ; Baumert, Ryan ; Ng, June ; Koo, Clara ; Arain, Urfa ; Behnia, Rudy ; Del Valle Rodriguez, Alberto ; Senderowicz, Lionel ; Negre, Nicolas ; White, Kevin P. ; Desplan, Claude. / Integration of temporal and spatial patterning generates neural diversity. In: Nature. 2017 ; Vol. 541, No. 7637. pp. 365-370.
@article{56b9cb532e02419083fda0422be26736,
title = "Integration of temporal and spatial patterning generates neural diversity",
abstract = "In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.",
author = "Ted Erclik and Xin Li and Maximilien Courgeon and Claire Bertet and Zhenqing Chen and Ryan Baumert and June Ng and Clara Koo and Urfa Arain and Rudy Behnia and {Del Valle Rodriguez}, Alberto and Lionel Senderowicz and Nicolas Negre and White, {Kevin P.} and Claude Desplan",
year = "2017",
month = "1",
day = "19",
doi = "10.1038/nature20794",
language = "English (US)",
volume = "541",
pages = "365--370",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7637",

}

TY - JOUR

T1 - Integration of temporal and spatial patterning generates neural diversity

AU - Erclik, Ted

AU - Li, Xin

AU - Courgeon, Maximilien

AU - Bertet, Claire

AU - Chen, Zhenqing

AU - Baumert, Ryan

AU - Ng, June

AU - Koo, Clara

AU - Arain, Urfa

AU - Behnia, Rudy

AU - Del Valle Rodriguez, Alberto

AU - Senderowicz, Lionel

AU - Negre, Nicolas

AU - White, Kevin P.

AU - Desplan, Claude

PY - 2017/1/19

Y1 - 2017/1/19

N2 - In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.

AB - In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.

UR - http://www.scopus.com/inward/record.url?scp=85011074761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011074761&partnerID=8YFLogxK

U2 - 10.1038/nature20794

DO - 10.1038/nature20794

M3 - Article

C2 - 28077877

AN - SCOPUS:85011074761

VL - 541

SP - 365

EP - 370

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7637

ER -