Integration of temporal and spatial patterning generates neural diversity

Ted Erclik, Xin Li, Maximilien Courgeon, Claire Bertet, Zhenqing Chen, Ryan Baumert, June Ng, Clara Koo, Urfa Arain, Rudy Behnia, Alberto Del Valle Rodriguez, Lionel Senderowicz, Nicolas Negre, Kevin P. White, Claude Desplan

Research output: Contribution to journalArticle

Abstract

In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: Uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: All neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalNature
Volume541
Issue number7637
DOIs
StatePublished - Jan 19 2017

ASJC Scopus subject areas

  • General

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    Erclik, T., Li, X., Courgeon, M., Bertet, C., Chen, Z., Baumert, R., Ng, J., Koo, C., Arain, U., Behnia, R., Del Valle Rodriguez, A., Senderowicz, L., Negre, N., White, K. P., & Desplan, C. (2017). Integration of temporal and spatial patterning generates neural diversity. Nature, 541(7637), 365-370. https://doi.org/10.1038/nature20794