TY - GEN
T1 - Integration of statistical models and visualization tools to characterize microRNA networks influencing cancer
AU - Karnia, James
AU - Delfino, Kristin R.
AU - Villamil, Maria Bonita
AU - Caetano-Anolles, Gustavo
AU - Rodriguez-Zas, Sandra Luisa
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Gene expression microarray experiments can be used to infer the topology of co-expression networks between genes in the immune-system pathways. Immune-system pathways are highly dimensional, including numerous gene nodes and edges connecting nodes. A bioinformatics strategy to infer and confirm gene co-expression networks was developed and applied to two major immune-system pathways. In total, 182 and 356 co-expression profiles between pairs of genes were identified in the NOD-like and B-cell receptor signaling pathways. The distinct distribution of the sign of the relationships among the pathways offered additional insights into the network.
AB - Gene expression microarray experiments can be used to infer the topology of co-expression networks between genes in the immune-system pathways. Immune-system pathways are highly dimensional, including numerous gene nodes and edges connecting nodes. A bioinformatics strategy to infer and confirm gene co-expression networks was developed and applied to two major immune-system pathways. In total, 182 and 356 co-expression profiles between pairs of genes were identified in the NOD-like and B-cell receptor signaling pathways. The distinct distribution of the sign of the relationships among the pathways offered additional insights into the network.
KW - B-cell receptor
KW - Cytokine
KW - NOD-like receptor
KW - chemokine
KW - microarray
UR - http://www.scopus.com/inward/record.url?scp=84856007676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856007676&partnerID=8YFLogxK
U2 - 10.1109/BIBMW.2011.6112541
DO - 10.1109/BIBMW.2011.6112541
M3 - Conference contribution
AN - SCOPUS:84856007676
SN - 9781457716133
T3 - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
SP - 1009
EP - 1011
BT - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
T2 - 2011 IEEE International Conference onBioinformatics and Biomedicine Workshops, BIBMW 2011
Y2 - 12 November 2011 through 15 November 2011
ER -