Abstract

Neuropeptides support inter-cell communication and have a role in many diverse biological processes. For pig, a biomedical model, few prohormones from which neuropeptides result after convertase processing are listed in the UniProt database. Therefore, our goals are to obtain an in silico library of pig prohormone and convertase genes and to functionally annotate these genes based on a large number of complementary gene expression microarray experiments. Using a bioinformatics pipeline, 101 prohormone genes and 8 convertase genes known in human, rat, mouse, chicken, and cow were located in the pig genome. Frequently (P-value < 0.005) differentially expressed prohormone genes included adrenomedullin (ADML), augurin (AUGN), neuropeptide Y (NPY), proenkephalin-A (PENK), parathyroid hormone-related protein (PTHR), and vascular endothelial growth factor C (VEGFC) and convertases (PCSK1 and PCSK7). Embryo and placental tissues displayed the most differentially expressed genes. Our genomic characterization allows the use of the pig as an effective animal model to gain a deeper understanding of neuropeptides.

Original languageEnglish (US)
Title of host publication2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Pages988-990
Number of pages3
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE International Conference onBioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States
Duration: Nov 12 2011Nov 15 2011

Publication series

Name2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Other

Other2011 IEEE International Conference onBioinformatics and Biomedicine Workshops, BIBMW 2011
CountryUnited States
CityAtlanta, GA
Period11/12/1111/15/11

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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