Integrating biocatalysis with chemocatalysis for selective transformations

Xiaoqiang Huang, Mingfeng Cao, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


The integration of biocatalysis with chemocatalysis combines the excellent selectivity of the former with the robust reactivity of the latter and offers many advantages, such as lower cost, higher yield, enhanced selectivity, as well as less waste generation. In spite of the challenge of incompatibilities between different classes of catalysts, recent advances in synthetic chemistry and biology provide ample opportunities for multistep cascade transformations that combine biocatalysis and chemocatalysis. Herein, we review recent progress in merging biocatalysis with chemocatalysis, highlighting selected examples of photo-/electricity-driven biotransformations and recently developed strategies for addressing the catalyst incompatibility issue.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalCurrent Opinion in Chemical Biology
StatePublished - Apr 2020


  • Biocatalysis
  • Cascade reactions
  • Chemocatalysis
  • Synergistic effect

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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