Integrated structural and functional optical imaging combining spectral-domain optical coherence and multiphoton microscopy

Claudio Vinegoni, Tyler Ralston, Wei Tan, Wei Luo, Daniel L. Marks, Stephen A. Boppart

Research output: Contribution to journalArticlepeer-review

Abstract

An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multiphoton microscopy for the detection of two-photon fluorescence and second harmonic generation signals. The unique configuration of this integrated microscope allows for the simultaneous acquisition of both anatomical (structural) and functional imaging information with particular emphasis for applications in the fields of tissue engineering and cell biology. In addition, the contemporary analysis of the spectroscopic features can enhance contrast by differentiating among different tissue components.

Original languageEnglish (US)
Article number053901
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Volume88
Issue number5
DOIs
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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