Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays

Yuhang Wan, John A. Carlson, Saoud A. Al-Mulla, Wang Peng, Kenneth D. Long, Benjamin A. Kesler, Patrick Su, John M. Dallesasse, Brian T. Cunningham

Research output: Contribution to journalArticle

Abstract

We describe the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications. As representative examples, the system is demonstrated for quantitatively measuring the liquids of a fetal fibronectin enzyme linked immunosorbent assay (ELISA) and for differentiating the color of pH test strips. A 3D-printed microfluidic cartridge comprised of a linear array of liquid compartments is demonstrated as a simple means for interfacing with the system, and for performing multiple measurements in series that can easily include experimental controls, concentration standards, and replicates.

LanguageEnglish (US)
Pages935-943
Number of pages9
JournalSensors and Actuators, B: Chemical
Volume255
DOIs
StatePublished - Feb 1 2018

Fingerprint

Spectroscopic analysis
spectroscopic analysis
Assays
Liquids
liquids
mobile communication systems
Color
color
cartridges
illuminators
Immunosorbents
tablets
environmental monitoring
Mobile telecommunication systems
Smartphones
sensors
Sensor arrays
linear arrays
compartments
Fibronectins

Keywords

  • Absorption
  • Color measurement
  • Medical optics instrumentation
  • Optical sensor
  • Spectrometers

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays. / Wan, Yuhang; Carlson, John A.; Al-Mulla, Saoud A.; Peng, Wang; Long, Kenneth D.; Kesler, Benjamin A.; Su, Patrick; Dallesasse, John M.; Cunningham, Brian T.

In: Sensors and Actuators, B: Chemical, Vol. 255, 01.02.2018, p. 935-943.

Research output: Contribution to journalArticle

Wan Y, Carlson JA, Al-Mulla SA, Peng W, Long KD, Kesler BA et al. Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays. Sensors and Actuators, B: Chemical. 2018 Feb 1;255:935-943. Available from, DOI: 10.1016/j.snb.2017.08.126
Wan, Yuhang ; Carlson, John A. ; Al-Mulla, Saoud A. ; Peng, Wang ; Long, Kenneth D. ; Kesler, Benjamin A. ; Su, Patrick ; Dallesasse, John M. ; Cunningham, Brian T./ Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays. In: Sensors and Actuators, B: Chemical. 2018 ; Vol. 255. pp. 935-943
@article{ff407364231a4df4b4eb3f6787839af6,
title = "Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays",
abstract = "We describe the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications. As representative examples, the system is demonstrated for quantitatively measuring the liquids of a fetal fibronectin enzyme linked immunosorbent assay (ELISA) and for differentiating the color of pH test strips. A 3D-printed microfluidic cartridge comprised of a linear array of liquid compartments is demonstrated as a simple means for interfacing with the system, and for performing multiple measurements in series that can easily include experimental controls, concentration standards, and replicates.",
keywords = "Absorption, Color measurement, Medical optics instrumentation, Optical sensor, Spectrometers",
author = "Yuhang Wan and Carlson, {John A.} and Al-Mulla, {Saoud A.} and Wang Peng and Long, {Kenneth D.} and Kesler, {Benjamin A.} and Patrick Su and Dallesasse, {John M.} and Cunningham, {Brian T.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.snb.2017.08.126",
language = "English (US)",
volume = "255",
pages = "935--943",
journal = "Sensors and Actuators, B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

TY - JOUR

T1 - Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays

AU - Wan,Yuhang

AU - Carlson,John A.

AU - Al-Mulla,Saoud A.

AU - Peng,Wang

AU - Long,Kenneth D.

AU - Kesler,Benjamin A.

AU - Su,Patrick

AU - Dallesasse,John M.

AU - Cunningham,Brian T.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - We describe the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications. As representative examples, the system is demonstrated for quantitatively measuring the liquids of a fetal fibronectin enzyme linked immunosorbent assay (ELISA) and for differentiating the color of pH test strips. A 3D-printed microfluidic cartridge comprised of a linear array of liquid compartments is demonstrated as a simple means for interfacing with the system, and for performing multiple measurements in series that can easily include experimental controls, concentration standards, and replicates.

AB - We describe the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications. As representative examples, the system is demonstrated for quantitatively measuring the liquids of a fetal fibronectin enzyme linked immunosorbent assay (ELISA) and for differentiating the color of pH test strips. A 3D-printed microfluidic cartridge comprised of a linear array of liquid compartments is demonstrated as a simple means for interfacing with the system, and for performing multiple measurements in series that can easily include experimental controls, concentration standards, and replicates.

KW - Absorption

KW - Color measurement

KW - Medical optics instrumentation

KW - Optical sensor

KW - Spectrometers

UR - http://www.scopus.com/inward/record.url?scp=85028422539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028422539&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2017.08.126

DO - 10.1016/j.snb.2017.08.126

M3 - Article

VL - 255

SP - 935

EP - 943

JO - Sensors and Actuators, B: Chemical

T2 - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

SN - 0925-4005

ER -