Abstract
A silicon single-chip microfluidics system that integrates microscale fluidic channels, an analyte segmentation device, and a nozzle for electrohydrodynamic-assisted printing is designed for hyphenation with MALDI mass spectrometry (MS) imaging. A miniaturized T-junction segments analytes into monodisperse picoliter oil-isolated compartments. The printing nozzle deposits generated droplets one-by-one into an array on a conductive substrate without splitting or coalescing. Virtually single-shot MS analysis is enabled due to the ultrasmall droplet volumes and highly localized printing. The signal-to-noise ratio indicates that detection limits at the attomole level are achieved for γ-aminobutyric acid.
Original language | English (US) |
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Pages (from-to) | 72-80 |
Number of pages | 9 |
Journal | Lab on a chip |
Volume | 23 |
Issue number | 1 |
DOIs | |
State | Published - Dec 7 2022 |
ASJC Scopus subject areas
- General Chemistry
- Bioengineering
- Biochemistry
- Biomedical Engineering