INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS

Yan Zhang; Yaoyao Zhao; Weihua Shi; Hrishikesh Iyer; Sungho Kim; Christopher Brenden; Insu Park; Stanislav Rubakhin; Rashid Bashir; Jonathan Sweedler; Yurii Vlasov

INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS

Yan Zhang, Yaoyao Zhao, Weihua Shi, Hrishikesh Iyer, Sungho Kim, Christopher Brenden, Insu Park, Stanislav Rubakhin, Rashid Bashir, Jonathan Sweedler, Yurii Vlasov

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We demonstrate a silicon-based microfluidic platform for interfacing of analyte segmentation and electrospray ionization to online mass spectrometry. Silicon microfabrication enables miniaturization and on-chip integration of scaled 7μm-radius microfluidic channels, a T-junction for analyte segmentation into picoliter-volume droplets at nL/min flow rates, and nano-electrospray nozzle for efficient droplet ionization. Single droplet analysis showed amol-level limits of neurochemicals detection.

Original language	English (US)
Title of host publication	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	55-56
Number of pages	2
ISBN (Electronic)	9781733419031
State	Published - 2021
Event	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States Duration: Oct 10 2021 → Oct 14 2021

Publication series

Name	MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/Territory	United States
City	Palm Springs, Virtual
Period	10/10/21 → 10/14/21

Keywords

Droplet microfluidics
Mass spectrometry
Nano-electrospray ionization
Silicon microfluidics

ASJC Scopus subject areas

Bioengineering
Chemical Engineering (miscellaneous)

Library availability

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Zhang, Y., Zhao, Y., Shi, W., Iyer, H., Kim, S., Brenden, C., Park, I., Rubakhin, S., Bashir, R., Sweedler, J., & Vlasov, Y. (2021). INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS. In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 55-56). (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS. / Zhang, Yan; Zhao, Yaoyao; Shi, Weihua et al.
MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2021. p. 55-56 (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zhang, Y, Zhao, Y, Shi, W, Iyer, H, Kim, S, Brenden, C, Park, I, Rubakhin, S , Bashir, R , Sweedler, J & Vlasov, Y 2021, INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 55-56, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21.

Zhang Y, Zhao Y, Shi W, Iyer H, Kim S, Brenden C et al. INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS. In MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2021. p. 55-56. (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Zhang, Yan ; Zhao, Yaoyao ; Shi, Weihua et al. / INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2021. pp. 55-56 (MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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abstract = "We demonstrate a silicon-based microfluidic platform for interfacing of analyte segmentation and electrospray ionization to online mass spectrometry. Silicon microfabrication enables miniaturization and on-chip integration of scaled 7μm-radius microfluidic channels, a T-junction for analyte segmentation into picoliter-volume droplets at nL/min flow rates, and nano-electrospray nozzle for efficient droplet ionization. Single droplet analysis showed amol-level limits of neurochemicals detection.",

keywords = "Droplet microfluidics, Mass spectrometry, Nano-electrospray ionization, Silicon microfluidics",

author = "Yan Zhang and Yaoyao Zhao and Weihua Shi and Hrishikesh Iyer and Sungho Kim and Christopher Brenden and Insu Park and Stanislav Rubakhin and Rashid Bashir and Jonathan Sweedler and Yurii Vlasov",

note = "Publisher Copyright: {\textcopyright} 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",

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language = "English (US)",

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AU - Zhang, Yan

AU - Zhao, Yaoyao

AU - Shi, Weihua

AU - Iyer, Hrishikesh

AU - Kim, Sungho

AU - Brenden, Christopher

AU - Park, Insu

AU - Rubakhin, Stanislav

AU - Bashir, Rashid

AU - Sweedler, Jonathan

AU - Vlasov, Yurii

PY - 2021

Y1 - 2021

N2 - We demonstrate a silicon-based microfluidic platform for interfacing of analyte segmentation and electrospray ionization to online mass spectrometry. Silicon microfabrication enables miniaturization and on-chip integration of scaled 7μm-radius microfluidic channels, a T-junction for analyte segmentation into picoliter-volume droplets at nL/min flow rates, and nano-electrospray nozzle for efficient droplet ionization. Single droplet analysis showed amol-level limits of neurochemicals detection.

AB - We demonstrate a silicon-based microfluidic platform for interfacing of analyte segmentation and electrospray ionization to online mass spectrometry. Silicon microfabrication enables miniaturization and on-chip integration of scaled 7μm-radius microfluidic channels, a T-junction for analyte segmentation into picoliter-volume droplets at nL/min flow rates, and nano-electrospray nozzle for efficient droplet ionization. Single droplet analysis showed amol-level limits of neurochemicals detection.

KW - Droplet microfluidics

KW - Mass spectrometry

KW - Nano-electrospray ionization

KW - Silicon microfluidics

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M3 - Conference contribution

AN - SCOPUS:85136960529

T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 55

EP - 56

BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

Y2 - 10 October 2021 through 14 October 2021

ER -

INTEGRATED SILICON CHIP ENABLING GENERATION AND ELECTROSPRAY OF PICOLITER DROPLETS FOR MASS-SPECTROMETRY ANALYSIS

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Library availability

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