TY - GEN
T1 - Instabilities in eye movement control
T2 - 11th Annual Conference on Neural Information Processing Systems, NIPS 1997
AU - Dow, Ernst R.
AU - Anastasio, Thomas J.
PY - 1998
Y1 - 1998
N2 - Nystagmus is a pattern of eye movement characterized by smooth rotations of the eye in one direction and rapid rotations in the opposite direction that reset eye position. Periodic alternating nystagmus (PAN) is a form of uncontrollable nystagmus that has been described as an unstable but amplitude-limited oscillation. PAN has been observed previously only in subjects with vestibulo-cerebellar damage. We describe results in which PAN can be produced in normal subjects by prolonged rotation in darkness. We propose a new model in which the neural circuits that control eye movement are inherently unstable, but this instability is kept in check under normal circumstances by the cerebellum. Circumstances which alter this cerebellar restraint, such as vestibulocerebellar damage or plasticity due to rotation in darkness, can lead to PAN.
AB - Nystagmus is a pattern of eye movement characterized by smooth rotations of the eye in one direction and rapid rotations in the opposite direction that reset eye position. Periodic alternating nystagmus (PAN) is a form of uncontrollable nystagmus that has been described as an unstable but amplitude-limited oscillation. PAN has been observed previously only in subjects with vestibulo-cerebellar damage. We describe results in which PAN can be produced in normal subjects by prolonged rotation in darkness. We propose a new model in which the neural circuits that control eye movement are inherently unstable, but this instability is kept in check under normal circumstances by the cerebellum. Circumstances which alter this cerebellar restraint, such as vestibulocerebellar damage or plasticity due to rotation in darkness, can lead to PAN.
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M3 - Conference contribution
AN - SCOPUS:0344192460
SN - 0262100762
SN - 9780262100762
T3 - Advances in Neural Information Processing Systems
SP - 138
EP - 144
BT - Advances in Neural Information Processing Systems 10 - Proceedings of the 1997 Conference, NIPS 1997
PB - Neural information processing systems foundation
Y2 - 1 December 1997 through 6 December 1997
ER -