TY - JOUR
T1 - Inspiring a convergent engineering approach to measure and model the tissue microenvironment
AU - Iyer, Rishyashring R.
AU - Applegate, Catherine C.
AU - Arogundade, Opeyemi H.
AU - Bangru, Sushant
AU - Berg, Ian C.
AU - Emon, Bashar
AU - Porras-Gomez, Marilyn
AU - Hsieh, Pei Hsuan
AU - Jeong, Yoon
AU - Kim, Yongdeok
AU - Knox, Hailey J.
AU - Moghaddam, Amir Ostadi
AU - Renteria, Carlos A.
AU - Richard, Craig
AU - Santaliz-Casiano, Ashlie
AU - Sengupta, Sourya
AU - Wang, Jason
AU - Zambuto, Samantha G.
AU - Zeballos, Maria A.
AU - Pool, Marcia
AU - Bhargava, Rohit
AU - Gaskins, H. Rex
N1 - This article was constructed as a part of the Tissue Microenvironment Training Program at the University of Illinois Urbana-Champaign, supported by a T32 grant from the National Institutes of Health and University of Illinois Urbana-Champaign. We would like to thank Dorothy R. Loudermilk for her help with the illustrations. We would like to acknowledge Profs. Stephen A. Boppart, John W. Erdman, Andrew Smith, Auinash Kalsotra, Gregory Underhill, Taher Saif, Rashid Bashir, Jefferson Chan, Thomas Gaj, Brendan Harley, Roy Dar, Hyunjoon Kong, Amy J. Wagoner Johnson, Joseph Irudayaraj, Zeynep Madak-Erdogan, and Mark Anastasio as the graduate advisors for the authors R.R.I \u2013 M.A.Z. We would like to thank Profs. Ioan Notingher, Stephen A. Boppart, Gabriel Popescu, Pengfei Song, Dirk Walther, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton for providing the example results for the figures.
This article was constructed as a part of the Tissue Microenvironment Training Program at the University of Illinois Urbana-Champaign, supported by a T32 grant from the National Institutes of Health and University of Illinois Urbana-Champaign (from the National Institute Of Biomedical Imaging And Bioengineering of the National Institutes of Health under Award Number T32EB019944). We would like to thank Dorothy R. Loudermilk for her help with the illustrations. We would like to acknowledge Profs. Stephen A. Boppart, John W. Erdman, Andrew Smith, Auinash Kalsotra, Gregory Underhill, Taher Saif, Rashid Bashir, Jefferson Chan, Thomas Gaj, Brendan Harley, Roy Dar, Hyunjoon Kong, Amy J. Wagoner Johnson, Joseph Irudayaraj, Zeynep Madak-Erdogan, and Mark Anastasio as the graduate advisors for the authors R.R.I \u2013 M.A.Z. We would like to thank Profs. Ioan Notingher, Stephen A. Boppart, Gabriel Popescu, Pengfei Song, Dirk Walther, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton for providing the example results for the figures.
PY - 2024/6/30
Y1 - 2024/6/30
N2 - Understanding the molecular and physical complexity of the tissue microenvironment (TiME) in the context of its spatiotemporal organization has remained an enduring challenge. Recent advances in engineering and data science are now promising the ability to study the structure, functions, and dynamics of the TiME in unprecedented detail; however, many advances still occur in silos that rarely integrate information to study the TiME in its full detail. This review provides an integrative overview of the engineering principles underlying chemical, optical, electrical, mechanical, and computational science to probe, sense, model, and fabricate the TiME. In individual sections, we first summarize the underlying principles, capabilities, and scope of emerging technologies, the breakthrough discoveries enabled by each technology and recent, promising innovations. We provide perspectives on the potential of these advances in answering critical questions about the TiME and its role in various disease and developmental processes. Finally, we present an integrative view that appreciates the major scientific and educational aspects in the study of the TiME.
AB - Understanding the molecular and physical complexity of the tissue microenvironment (TiME) in the context of its spatiotemporal organization has remained an enduring challenge. Recent advances in engineering and data science are now promising the ability to study the structure, functions, and dynamics of the TiME in unprecedented detail; however, many advances still occur in silos that rarely integrate information to study the TiME in its full detail. This review provides an integrative overview of the engineering principles underlying chemical, optical, electrical, mechanical, and computational science to probe, sense, model, and fabricate the TiME. In individual sections, we first summarize the underlying principles, capabilities, and scope of emerging technologies, the breakthrough discoveries enabled by each technology and recent, promising innovations. We provide perspectives on the potential of these advances in answering critical questions about the TiME and its role in various disease and developmental processes. Finally, we present an integrative view that appreciates the major scientific and educational aspects in the study of the TiME.
KW - Bioengineering
KW - Bioimaging
KW - Biomaterials
KW - Biomedical devices
KW - Biosensing
KW - Biotechnology
KW - Computational biology
KW - Interdisciplinary research
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U2 - 10.1016/j.heliyon.2024.e32546
DO - 10.1016/j.heliyon.2024.e32546
M3 - Review article
C2 - 38975228
AN - SCOPUS:85195653331
SN - 2405-8440
VL - 10
JO - Heliyon
JF - Heliyon
IS - 12
M1 - e32546
ER -