Inositol polyphosphate multikinase: An emerging player for the central action of AMP-activated protein kinase

Megan J. Dailey, Seyun Kim

Research output: Contribution to journalShort surveypeer-review

Abstract

AMP-activated protein kinase (AMPK) is an essential enzyme indispensable for energy sensing and metabolic homeostasis at both the cellular and whole-body levels. Phosphorylation of AMPK, a key step for its activation, is known to be regulated by upstream kinases such as liver kinase B1 (LKB1) and calmodulin-dependent protein kinase kinase-beta (CaMKKβ). Recent evidence shows that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid inositol kinase activities, can physiologically regulate AMPK signaling in cultured cells and in the arcuate nucleus. IPMK-mediated regulation of AMPK occurs through the dynamic protein interactions of IPMK with AMPK in response to glucose availability. Here we review and discuss a novel role for the hypothalamic IPMK signaling in the control of AMPK and central energy homeostasis.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume421
Issue number1
DOIs
StatePublished - Apr 27 2012

Keywords

  • AMPK
  • Energy homeostasis
  • Food intake
  • IPMK

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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