Inorganic delivery vector for intravenous injection

Seo Young Kwak; Waltraud M. Kriven; Matthew A. Wallig; Jin Ho Choy

doi:10.1016/j.biomaterials.2004.01.056

Inorganic delivery vector for intravenous injection

Seo Young Kwak, Waltraud M. Kriven, Matthew A. Wallig, Jin Ho Choy

Research output: Contribution to journal › Article › peer-review

Abstract

Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of 1 and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate the possibility of using LDH as an injectable drug delivery vehicle.

Original language	English (US)
Pages (from-to)	5995-6001
Number of pages	7
Journal	Biomaterials
Volume	25
Issue number	28
DOIs	https://doi.org/10.1016/j.biomaterials.2004.01.056
State	Published - Dec 2004

Keywords

Drug delivery
In vivo testing
Nanoparticle
SEM
TEM

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

Online availability

10.1016/j.biomaterials.2004.01.056

Library availability

Discover UIUC Full Text

Cite this

@article{e1a922754c7f461385211909ea118b01,

title = "Inorganic delivery vector for intravenous injection",

abstract = "Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of 1 and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate the possibility of using LDH as an injectable drug delivery vehicle.",

keywords = "Drug delivery, In vivo testing, Nanoparticle, SEM, TEM",

author = "Kwak, {Seo Young} and Kriven, {Waltraud M.} and Wallig, {Matthew A.} and Choy, {Jin Ho}",

note = "Funding Information: This work was supported by a Grant from the Illinois Governor's Venture Technology Fund. S.Y. Kwak acknowledges partial support by a Postdoctoral Fellowship from the Korea Science and Engineering Foundation (KOSEF). J.H. Choy expresses his thanks to the Ministry of Science and Technology, Korea for financial support through a National Research Laboratory Project {\textquoteright}99. The electron microscopy was carried out in the Frederick Seitz Materials Research Laboratory, Center for Microanalysis of Materials, University of Illinois, which is partially supported by the US Department of Energy under Grant DEFG02-91-ER45439. ",

year = "2004",

month = dec,

doi = "10.1016/j.biomaterials.2004.01.056",

language = "English (US)",

volume = "25",

pages = "5995--6001",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier BV",

number = "28",

}

TY - JOUR

T1 - Inorganic delivery vector for intravenous injection

AU - Kwak, Seo Young

AU - Kriven, Waltraud M.

AU - Wallig, Matthew A.

AU - Choy, Jin Ho

N1 - Funding Information: This work was supported by a Grant from the Illinois Governor's Venture Technology Fund. S.Y. Kwak acknowledges partial support by a Postdoctoral Fellowship from the Korea Science and Engineering Foundation (KOSEF). J.H. Choy expresses his thanks to the Ministry of Science and Technology, Korea for financial support through a National Research Laboratory Project ’99. The electron microscopy was carried out in the Frederick Seitz Materials Research Laboratory, Center for Microanalysis of Materials, University of Illinois, which is partially supported by the US Department of Energy under Grant DEFG02-91-ER45439.

PY - 2004/12

Y1 - 2004/12

N2 - Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of 1 and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate the possibility of using LDH as an injectable drug delivery vehicle.

AB - Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of 1 and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate the possibility of using LDH as an injectable drug delivery vehicle.

KW - Drug delivery

KW - In vivo testing

KW - Nanoparticle

KW - SEM

KW - TEM

UR - http://www.scopus.com/inward/record.url?scp=2942546146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942546146&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2004.01.056

DO - 10.1016/j.biomaterials.2004.01.056

M3 - Article

C2 - 15183614

AN - SCOPUS:2942546146

SN - 0142-9612

VL - 25

SP - 5995

EP - 6001

JO - Biomaterials

JF - Biomaterials

IS - 28

ER -

Inorganic delivery vector for intravenous injection

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this