Inorganic delivery vector for intravenous injection

Seo Young Kwak, Waltraud M. Kriven, Matthew A. Wallig, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

Abstract

Uniform, small-sized (100-200nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of 1 and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate the possibility of using LDH as an injectable drug delivery vehicle.

Original languageEnglish (US)
Pages (from-to)5995-6001
Number of pages7
JournalBiomaterials
Volume25
Issue number28
DOIs
StatePublished - Dec 2004

Keywords

  • Drug delivery
  • In vivo testing
  • Nanoparticle
  • SEM
  • TEM

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials

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