TY - JOUR
T1 - Innovations in CRISPR technology
AU - Brooks, Alexandra K.
AU - Gaj, Thomas
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/8
Y1 - 2018/8
N2 - CRISPR-Cas9 is a versatile tool for genome engineering that has revolutionized biotechnology and is poised to impact medicine. Recent advances in the identification of unique CRISPR systems, as well as the re-engineering of the Cas9 protein for expanded function, has enabled the diversification of the CRISPR genome engineering toolbox. In this review, we highlight these innovations and discuss how advances in CRISPR technology can lead to breakthroughs in the field of gene therapy.
AB - CRISPR-Cas9 is a versatile tool for genome engineering that has revolutionized biotechnology and is poised to impact medicine. Recent advances in the identification of unique CRISPR systems, as well as the re-engineering of the Cas9 protein for expanded function, has enabled the diversification of the CRISPR genome engineering toolbox. In this review, we highlight these innovations and discuss how advances in CRISPR technology can lead to breakthroughs in the field of gene therapy.
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U2 - 10.1016/j.copbio.2018.03.007
DO - 10.1016/j.copbio.2018.03.007
M3 - Review article
C2 - 29626736
AN - SCOPUS:85044919513
SN - 0958-1669
VL - 52
SP - 95
EP - 101
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -