Innate immune system recognition of microbial pathogens

P. S. Tobias, H. K. Lee, S. Orr, K. Soldau, R. Tapping

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The long-term goal of our laboratory is to understand vertebrate host recognition of microbial pathogens. Although our work is primarily curiosity driven, it is certainly true that understanding how a host recognizes microbial pathogens should have some medical application. Probably more than 50,000 people die each year in the United States of septic shock or the systemic inflammatory response syndrome, and there is no good therapy for this problem. Understanding the molecular basis of its origin should suggest novel therapeutic approaches.

    Original languageEnglish (US)
    Pages (from-to)341-343
    Number of pages3
    JournalImmunologic Research
    Volume21
    Issue number2-3
    DOIs
    StatePublished - 2000

    Keywords

    • CD14
    • Endotoxin
    • Innate immune system
    • Septic shock
    • Toll
    • Toll-like receptors

    ASJC Scopus subject areas

    • Immunology

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