Innate immune system recognition of microbial pathogens

P. S. Tobias, H. K. Lee, S. Orr, K. Soldau, R. Tapping

Research output: Contribution to journalArticlepeer-review

Abstract

The long-term goal of our laboratory is to understand vertebrate host recognition of microbial pathogens. Although our work is primarily curiosity driven, it is certainly true that understanding how a host recognizes microbial pathogens should have some medical application. Probably more than 50,000 people die each year in the United States of septic shock or the systemic inflammatory response syndrome, and there is no good therapy for this problem. Understanding the molecular basis of its origin should suggest novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalImmunologic Research
Volume21
Issue number2-3
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • CD14
  • Endotoxin
  • Innate immune system
  • Septic shock
  • Toll
  • Toll-like receptors

ASJC Scopus subject areas

  • Immunology

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