Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans

J. F. Brinkworth, E. A. Pechenkina, J. Silver, S. M. Goyert

Research output: Contribution to journalArticlepeer-review

Abstract

Background: African catarrhine primates differ in bacterial disease susceptibility. Methods: Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR. Results: Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent. Conclusions: These primates tend to generate species rather than agonist-specific responses to bacterial agonists.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalJournal of Medical Primatology
Volume41
Issue number6
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • Bacteria
  • Chemokines
  • Cytokines
  • Escherichia coli
  • Innate immunity
  • Mycobacterium
  • Primate immunity
  • Toll-like receptors

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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