Inhibitory ligand-gated ion channels as substrates for general anesthetic actions

A. Zeller, R. Jurd, S. Lambert, M. Arras, B. Drexler, C. Grashoff, B. Antkowiak, U. Rudolph

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)A receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.

Original languageEnglish (US)
Title of host publicationModern Anesthetics
PublisherSpringer Science and Business Media, LLC
Pages31-51
Number of pages21
ISBN (Print)9783540728139
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume182
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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