Inhibitory ligand-gated ion channels as substrates for general anesthetic actions

A. Zeller, R. Jurd, S. Lambert, M. Arras, B. Drexler, C. Grashoff, B. Antkowiak, U. Rudolph

Research output: Chapter in Book/Report/Conference proceedingChapter


General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)A receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.

Original languageEnglish (US)
Title of host publicationModern Anesthetics
Number of pages21
ISBN (Print)9783540728139
StatePublished - 2008
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Biochemistry


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