General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)A receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.
|Original language||English (US)|
|Title of host publication||Modern Anesthetics|
|Number of pages||21|
|State||Published - 2008|
|Name||Handbook of Experimental Pharmacology|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)