Inhibitory effects of acetaminophen, 7,8-benzoflavone and methimazole towards N-nitrosodimethylamine mutagenesis in Arabidopsis thaliana

T. Gichner, J. Velemínský, E. D. Wagner, M. J. Plewa

Research output: Contribution to journalArticle

Abstract

The metabolic inhibitors acetaminophen, 7,8-benzoflavone, and methimazle significantly reduced the mutagenicity of the promutagen N-nitrosodimethylamine in the higher plant Arabidopsis thaliana. In contrast, these metabolic inhibitors had no effect on the mutagenicity of the direct-acting mutagen N-methyl-N′-nitro-N-nitrosoguanidine.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalMutation Research/Genetic Toxicology
Volume300
Issue number1
DOIs
StatePublished - Jun 1993

Keywords

  • 7,8-Benzoflavone
  • Acetaminophen
  • Arabidopsis thaliana
  • Methimazole
  • Mutagenicity inhibition

ASJC Scopus subject areas

  • Toxicology
  • Genetics

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