Inhibition of virus-induced age-dependent poliomyelitis by interferon-γ

William A. Cafruny, Thomas R. Haven, Steven R. Lawson, Grace H.W. Wong, Raymond R.R. Rowland

Research output: Contribution to journalArticlepeer-review

Abstract

Age-dependent poliomyelitis (ADPM) is a neuroparolytic disease which results from combined infection of susceptible mice with lactate dehydrogenase-elevating virus (LDV) and murine leukemia virus (MuLV). The present study examined the effects of interferon-γ (IFN-γ) treatment on the incidence of ADPM, replication of LDV and MuLV and anti-LDV immunity. IFN-γ treatment of ADPM-susceptible C58/M mice protected them from paralytic disease, but had no detectable effect on the IgG anti-LDV response or LDV viremia. IFN-γ-mediated protection from ADPM correlated with reduced expression of LDV RNA, but not MuLV RNA, in the spinal cords of C58/M mice. These results confirm that spinal cord LDV replication is the determinant of ADPM and demonstrate that cytokine-mediated inhibition of LDV replication in the central nervous system prevents neuroparalytic disease.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAntiviral Research
Volume36
Issue number1
DOIs
StatePublished - Oct 1 1997
Externally publishedYes

Keywords

  • Age-dependent poliomyelitis
  • Interferon-γ
  • Lactate dehydrogenase-elevating virus

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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