Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity

Keyphrases

• Small Molecules 100%
• Irradiation 100%
• Transcription Factor 100%
• DNA Binding 100%
• P53 DNA Binding 100%
• Radiation Toxicity 100%
• IC50 50%
• Binding Site 50%
• Therapeutic Target 50%
• Chemotherapy 50%
• Drug Treatment 50%
• Small Molecule Inhibitors 50%
• Negative Feedback Loop 50%
• Transcriptional Output 50%
• Acute Toxicity 50%
• Cell-free 50%
• E2F Transcription Factor 1 (E2F1) 50%
• Murine Double Minute 2 (MDM2) 50%
• Sequence-specific DNA Binding 50%
• High-throughput Screening Assays 50%
• Drug-like 50%
• Druggability 50%
• Inhibitor of DNA Binding 50%
• Chemotherapy Drugs 50%
• TCF1 50%

Biochemistry, Genetics and Molecular Biology

• DNA Binding 100%
• Small Molecule 100%
• P53 100%
• Transcription Factors 25%
• Binding Site 12%
• High Throughput Screening 12%
• IC50 12%
• P73 12%
• Single Drug Dose 12%
• E2F1 12%
• Drug Therapy 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Radiation Toxicity 100%
• Chemotherapy 25%
• Transcription Factors 25%
• IC50 12%
• Binding Site 12%
• High-Throughput Screening 12%
• Pharmacotherapy 12%
• Acute Toxicity 12%