Inhibition of Leishmania mexicana growth by the tuberculosis drug SQ109

Verónica García-García; Eric Oldfield; Gustavo Benaim

doi:10.1128/AAC.00945-16

Inhibition of Leishmania mexicana growth by the tuberculosis drug SQ109

Verónica García-García, Eric Oldfield, Gustavo Benaim

Chemistry

Research output: Contribution to journal › Article

Abstract

We report that the tuberculosis drug SQ109 [N-adamantan-2-yl-N′-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine] has potent activity against the intracellular amastigote form of Leishmania mexicana (50% inhibitory concentration [IC₅₀], ∼11 nM), with a good selectivity index (>500). It is also active against promastigotes (IC₅₀, ∼500 nM) and acts as a protonophore uncoupler, in addition to disrupting Ca²⁺ homeostasis by releasing organelle Ca²⁺ into the cytoplasm, and as such, it is an interesting new leishmaniasis drug hit candidate.

Original language	English (US)
Pages (from-to)	6386-6389
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00945-16
State	Published - Oct 2016

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ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Cite this

García-García, V., Oldfield, E., & Benaim, G. (2016). Inhibition of Leishmania mexicana growth by the tuberculosis drug SQ109. Antimicrobial Agents and Chemotherapy, 60(10), 6386-6389. https://doi.org/10.1128/AAC.00945-16

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10.1128/AAC.00945-16