Inhibition of Growth by Pro-Inflammatory Cytokines: An Integrated View

Research output: Contribution to journalArticlepeer-review

Abstract

In response to antigenic stimuli, a variety of cells, including activated macrophages, secrete cytokines that are responsible for altering the host's metabolism. Three of these cytokines (tumor necrosis factor alpha [TNF-α], interleukin-1 [IL-1], and interleukin-6 [IL-6]) have profound behavioral, neuroendocrine, and metabolic effects. There is evidence that cytokines and their cognate receptors are present in the neuroendocrine system and brain. Moreover, in laboratory animal species, IL-1, IL-6, and TNF-α have been found to modulate intermediary metabolism of carbohydrate, fat, and protein substrates, regulate hypothalamic-pituitary outflow, and act in the brain to reduce food intake. Finally, many of the systemic acute-phase responses to inflammatory stimuli such as lipopolysaccharide are inhibited by treatment with cytokine receptor antagonists. In short, many findings converge to suggest that a major component of the growth inhibition observed in immunologically challenged animals is mediated by pro-inflammatory cytokines. The goal of this article is to provide an integrated view of how cytokines act systemically on disparate tissues to alter growth.

Original languageEnglish (US)
Pages (from-to)1244-1255
Number of pages12
JournalJournal of animal science
Volume75
Issue number5
DOIs
StatePublished - May 1997

Keywords

  • Central Nervous System
  • Cytokines
  • Food Intake
  • Growth
  • Metabolism
  • Stress

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

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