Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein

M. S. Davis, Jr Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

Escherichia coli acetyl coenzyme A carboxylase (ACC), the first enzyme of the fatty acid biosynthetic pathway, is inhibited by acylated derivatives of acyl carrier protein (ACP). ACP lacking an acyl moiety does not inhibit ACC. Acylated derivatives of ACP having chain lengths of 6 to 20 carbon atoms were similarly inhibitory at physiologically relevant concentrations. The observed feedback inhibition was specific to the protein moiety, as shown by the inability of the palmitoyl thioester of spinach ACP I to inhibit ACC.

Original languageEnglish (US)
Pages (from-to)1499-1503
Number of pages5
JournalJournal of bacteriology
Volume183
Issue number4
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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