Inhibition of α-glucosidase and α-amylase by Vaccinium floribundum and Aristotelia chilensis proanthocyanidins

Maria Schreckinger, Mary Ann Lila, Gad Yousef, Elvira De Mejia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Extracts from Vaccinum floribundum and Aristotelia chilensis, two promising South American berry species, were characterized in terms of their phytochemical composition and ability to inhibit α-glucosidase and α-amylase activities in vitro. A. chilensis contained 45.7 mg/g DW total anthocyanins (cyanidin-3-glucososide (C3G) equivalents). Seven anthocyanins were identified in this berry, of which delphinidin-3-glucoside was the main anthocyanin. A. chilensis contained proanthocyanidin dimers (56%) and trimers (14%). V. floribundum was comprised of trimers (68%) and in less proportion pentamers (16%) and hexamers (8%). V. floribundum proanthocyanidins inhibited both α-glucosidase (IC50=35 μg/mL) and α-amylase (IC50=25 μg/mL), which warrants further research into potential dietary use of this berry in therapies to combat diabetes symptoms.

Original languageEnglish (US)
Title of host publicationHispanic Foods
Subtitle of host publicationChemistry and Bioactive Compounds
PublisherAmerican Chemical Society
Pages71-82
Number of pages12
ISBN (Print)9780841227460
DOIs
StatePublished - Nov 15 2012

Publication series

NameACS Symposium Series
Volume1109
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

Fingerprint

Anthocyanins
Glucosidases
Enzyme inhibition
Proanthocyanidins
Amylases
Phytochemicals
Medical problems
Dimers
Chemical analysis

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Schreckinger, M., Lila, M. A., Yousef, G., & De Mejia, E. (2012). Inhibition of α-glucosidase and α-amylase by Vaccinium floribundum and Aristotelia chilensis proanthocyanidins. In Hispanic Foods: Chemistry and Bioactive Compounds (pp. 71-82). (ACS Symposium Series; Vol. 1109). American Chemical Society. https://doi.org/10.1021/bk-2012-1109.ch006

Inhibition of α-glucosidase and α-amylase by Vaccinium floribundum and Aristotelia chilensis proanthocyanidins. / Schreckinger, Maria; Lila, Mary Ann; Yousef, Gad; De Mejia, Elvira.

Hispanic Foods: Chemistry and Bioactive Compounds. American Chemical Society, 2012. p. 71-82 (ACS Symposium Series; Vol. 1109).

Research output: Chapter in Book/Report/Conference proceedingChapter

Schreckinger, M, Lila, MA, Yousef, G & De Mejia, E 2012, Inhibition of α-glucosidase and α-amylase by Vaccinium floribundum and Aristotelia chilensis proanthocyanidins. in Hispanic Foods: Chemistry and Bioactive Compounds. ACS Symposium Series, vol. 1109, American Chemical Society, pp. 71-82. https://doi.org/10.1021/bk-2012-1109.ch006
Schreckinger M, Lila MA, Yousef G, De Mejia E. Inhibition of α-glucosidase and α-amylase by Vaccinium floribundum and Aristotelia chilensis proanthocyanidins. In Hispanic Foods: Chemistry and Bioactive Compounds. American Chemical Society. 2012. p. 71-82. (ACS Symposium Series). https://doi.org/10.1021/bk-2012-1109.ch006
Schreckinger, Maria ; Lila, Mary Ann ; Yousef, Gad ; De Mejia, Elvira. / Inhibition of α-glucosidase and α-amylase by Vaccinium floribundum and Aristotelia chilensis proanthocyanidins. Hispanic Foods: Chemistry and Bioactive Compounds. American Chemical Society, 2012. pp. 71-82 (ACS Symposium Series).
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