Influence of ketamine on the cardiopulmonary effects of intramuscular administration of dexmedetomidine-buprenorphine with subsequent reversal with atipamezole in dogs

Jeff C. Ko, Michele Barletta, Ismail Sen, Ann B. Weil, Rebecca A. Krimins, Mark E. Payton, Peter Constable

Research output: Contribution to journalArticle

Abstract

Objective-To compare the cardiorespiratory effects of IM administration of dexmedeto- midine-buprenorphine (DB) and dexmedetomidine-buprenorphine-ketamine (DBK) in dogs with subsequent reversal with atipamezole. Design-Prospective, randomized crossover study. Animals-5 healthy dogs. Procedures-Dogs were instrumented for cardiac output (CO) measurement and received DB (15 μg of dexmedetomidine/kg [6.8 μg/lb] and 40 μg of buprenorphine/kg [18.2 μg/lb]) or DBK (DB plus 3 mg of ketamine/kg [1.36 mg/lb]) in randomized order while breathing room air. Atipamezole (150 μg/kg [68.2 μg/lb], IM) was administered 1 hour later. Hemodynamic da fat tear wd reurge acdomlleincitsetdra itni o tnh.e L caocntastcei o cuosn dceongtsraatniodn t hweans a mt.5e,as1u0r, e1d5,in20m, i3xe0d, 4v5e,n aonuds 6b0lo modin suatmes- ples. Oxygen delivery (DO2) and oxygen consumption (VO2) were calculated. Results-Heart rate (HRO)2, CO, and D decreased afteOr2 DB and DBK administration. The VO2 did not change in the DB group buOt 2decreased in the DBK group. The HR was. higher in the DBK group than in the DB group throughout the study, but the CO, DO2, and VO2 values O2 O2 were similar for the 2 groups. Blood lactate concentrations remained low (< 1 mmol/L) throughout the study. Arterial hypoxemia and hypercapnea occurred in both groups. Mean arterial blood pressure and pulmonary artery wedge pressure were markedly increased in both groups, but to a greater extent in the DBK group. After atipamezole administration, HR, CO, and DO2 returned to the baseline values. O2 Conclusions and Clinical Relevance-Adding ketamine to the DB combination allowed dogs to maintain a higher HR and delayed the onset of sinus arrhythmias but failed to provide a significantly higher CO because of a reduction in stroke volume.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume242
Issue number3
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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