Objective To evaluate the influence of fentanyl on intra-abdominal pressures in spontaneously breathing dogs during capnoperitoneum. Study design Prospective clinical study. Animals Eleven healthy client-owned and five healthy experimental dogs undergoing laparoscopy. Methods Dogs were premedicated with acepromazine (0.03mgkg-1 IV) and carprofen (4mgkg-1 IV). Anaesthesia was induced with propofol and maintained with isoflurane in oxygen. The abdomen was insufflated with CO2 (11-16cm H2O). Intra-abdominal pressures were measured with a transducer. Respiratory variables were measured with a spirometry sensor and side-stream capnography. Following preparation, fentanyl (1μgkg-1) was injected over 30seconds IV. Data were recorded 5minutes before, during and 5minutes after treatment. The following time points were selected for statistical analysis (anova, p<0.05): -160, -140, -120, -100, -80, -60, -40, -20, 0, 30, 50, 70, 90, 110, 130 and 150seconds after the start of fentanyl injection. Results Intra-abdominal pressure increased during inspiration in 15 dogs but decreased in one dog. Fentanyl treatment did not alter these patterns. Peak inspiratory and end-expiratory intra-abdominal pressures continuously decreased over time during the whole experiment and fentanyl exaggerated the decrease in inspiratory pressures but did not affect the rate of decrease in expiratory pressures. Differences between intra-abdominal pressures were stable before, but decreased after fentanyl administration from 4.1±1.4 to 3.3±1.2cm H2O (at 0 and 150seconds time points). End-tidal CO2 partial pressures increased from 6.0±0.8 to 6.6±0.9kPa, respiratory rate decreased from 10.8±2.6 to 7.8±2.2 breaths per minute and tidal volume decreased from 13.7±4.4 to 12.4±2.9mLkg-1 after fentanyl but these variables did not change before fentanyl treatment. Airway pressures did not change. Conclusions and clinical relevance Fentanyl did not increase intra-abdominal pressures in dogs.
- Intra-abdominal pressure
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