TY - JOUR
T1 - Influence of anesthetic variables on short-term and overall survival rates in cats undergoing renal transplantation surgery
AU - Snell, William
AU - Aronson, Lillian
AU - Phillips, Heidi
AU - Beale, Lynne
AU - Menzies, M. Paula Larenza
N1 - Publisher Copyright:
© 2015, American Veterinary Medical Association. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Objective—To identify factors associated with short-term (30-day) and overall survival rates in cats that underwent renal transplantation surgery (RTS). Design—Retrospective cohort study. Animals—94 cats that underwent RTS from 1998 through 2010. Procedures—Data obtained from the medical records pertinent to RTS included cat signalment; anesthetic agents, techniques, and timings; supportive treatment; perioperative physiologic findings; and surgery and warm ischemia times. Associations with short-term and overall survival rates were investigated. Results—Median survival time was 653 days (range, 2 to 4,580 days). Prolonged anesthesia (median, 300 minutes; range, 225 to 445 minutes) reduced overall survival rate but did not influence short-term survival rate. No associations were identified between survival rates and anesthetic agent used, amount and type of fluid administered IV, physiologic abnormalities, and blood product administration. All cats that received μ-opioid receptor antagonists at anesthetic recovery to reverse the effects of μ-opioid receptor agonists survived for at least 30 days. High Hct at the end of anesthesia was also associated with an increase in short-term survival rate. Two cats had an intraoperative hemoglobin oxygen saturation < 90%, and both died within 7 days after surgery. Cats > 12 years old had a lower overall survival rate than did younger cats. Conclusions and Clinical Relevance—Minimization of total anesthesia time, reversal of μ-opioid receptor agonists at the end of anesthesia, and prevention of intraoperative decreases in blood oxygen saturation and postoperative decreases in Hct appeared to help maximize postsurgical survival time in cats undergoing RTS.
AB - Objective—To identify factors associated with short-term (30-day) and overall survival rates in cats that underwent renal transplantation surgery (RTS). Design—Retrospective cohort study. Animals—94 cats that underwent RTS from 1998 through 2010. Procedures—Data obtained from the medical records pertinent to RTS included cat signalment; anesthetic agents, techniques, and timings; supportive treatment; perioperative physiologic findings; and surgery and warm ischemia times. Associations with short-term and overall survival rates were investigated. Results—Median survival time was 653 days (range, 2 to 4,580 days). Prolonged anesthesia (median, 300 minutes; range, 225 to 445 minutes) reduced overall survival rate but did not influence short-term survival rate. No associations were identified between survival rates and anesthetic agent used, amount and type of fluid administered IV, physiologic abnormalities, and blood product administration. All cats that received μ-opioid receptor antagonists at anesthetic recovery to reverse the effects of μ-opioid receptor agonists survived for at least 30 days. High Hct at the end of anesthesia was also associated with an increase in short-term survival rate. Two cats had an intraoperative hemoglobin oxygen saturation < 90%, and both died within 7 days after surgery. Cats > 12 years old had a lower overall survival rate than did younger cats. Conclusions and Clinical Relevance—Minimization of total anesthesia time, reversal of μ-opioid receptor agonists at the end of anesthesia, and prevention of intraoperative decreases in blood oxygen saturation and postoperative decreases in Hct appeared to help maximize postsurgical survival time in cats undergoing RTS.
UR - http://www.scopus.com/inward/record.url?scp=84937485281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937485281&partnerID=8YFLogxK
U2 - 10.2460/javma.247.3.267
DO - 10.2460/javma.247.3.267
M3 - Article
C2 - 26176726
AN - SCOPUS:84937485281
SN - 0003-1488
VL - 247
SP - 267
EP - 277
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
IS - 3
ER -