TY - JOUR
T1 - Inflammation and intestinal function
T2 - Where does it start and what does it mean?
AU - Tappenden, Kelly A.
N1 - Funding Information:
The 2008 Intersociety Research Workshop: Nutrition and Inflammation: Research Makes the Connection, was supported by grant number U13DK064190 from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health.
PY - 2008/11
Y1 - 2008/11
N2 - Various key elements of intestinal function, such as digestion, absorption, and barrier function, are impaired during inflammation. Although intestinal damage associated with inflammation originating within the intestine is well-known, inflammation in distant organs can impair intestinal function, despite normal histological appearance of the impacted intestinal mucosa. Widespread clinical dogma indicating that intestinal dysfunction drives inflammation should be reconsidered based on data indicating that, in many situations, inflammation precedes intestinal damage and appears to be the injurious factor. Finally, various nutrients have been shown to protect and/or repair the intestinal mucosa from the effects of inflammation; therefore, strategies for optimizing the nutrients provided during inflammatory states should be considered.
AB - Various key elements of intestinal function, such as digestion, absorption, and barrier function, are impaired during inflammation. Although intestinal damage associated with inflammation originating within the intestine is well-known, inflammation in distant organs can impair intestinal function, despite normal histological appearance of the impacted intestinal mucosa. Widespread clinical dogma indicating that intestinal dysfunction drives inflammation should be reconsidered based on data indicating that, in many situations, inflammation precedes intestinal damage and appears to be the injurious factor. Finally, various nutrients have been shown to protect and/or repair the intestinal mucosa from the effects of inflammation; therefore, strategies for optimizing the nutrients provided during inflammatory states should be considered.
KW - Digestion
KW - Entrocyte
KW - Inflammation
KW - Intestinal barrier function
KW - Mucosa
KW - Nutrients
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U2 - 10.1177/0148607108325177
DO - 10.1177/0148607108325177
M3 - Article
C2 - 18974246
AN - SCOPUS:54249104930
VL - 32
SP - 648
EP - 650
JO - Journal of Parenteral and Enteral Nutrition
JF - Journal of Parenteral and Enteral Nutrition
SN - 0148-6071
IS - 6
ER -