Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe

Danielle E. Campbell, Lindsey K. Ly, Jason M. Ridlon, Ansel Hsiao, Rachel J. Whitaker, Patrick H. Degnan

Research output: Contribution to journalArticlepeer-review

Abstract

Integrative phages can have myriad effects on bacterial hosts. Campbell et al. find that integration of Bacteroides phage BV01 into Bacteroides vulgatus disrupts expression of TspO, reducing bile acid deconjugation. This is predicted to affect gut colonization and interactions with the human host. BV01 belongs to the Salyersviridae family.

Original languageEnglish (US)
Article number108142
JournalCell Reports
Volume32
Issue number11
DOIs
StatePublished - Sep 15 2020

Keywords

  • Bacteroides
  • bacteriophage
  • bile acids
  • gut microbiome
  • host-microbe interactions
  • phage-host interactions
  • temperate phage

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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