Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe

Danielle E. Campbell; Lindsey K. Ly; Jason M. Ridlon; Ansel Hsiao; Rachel J. Whitaker; Patrick H. Degnan

doi:10.1016/j.celrep.2020.108142

Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe

Danielle E. Campbell, Lindsey K. Ly, Jason M. Ridlon, Ansel Hsiao, Rachel J. Whitaker, Patrick H. Degnan

Research output: Contribution to journal › Article › peer-review

Abstract

Integrative phages can have myriad effects on bacterial hosts. Campbell et al. find that integration of Bacteroides phage BV01 into Bacteroides vulgatus disrupts expression of TspO, reducing bile acid deconjugation. This is predicted to affect gut colonization and interactions with the human host. BV01 belongs to the Salyersviridae family.

Original language	English (US)
Article number	108142
Journal	Cell Reports
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2020.108142
State	Published - Sep 15 2020

Keywords

Bacteroides
bacteriophage
bile acids
gut microbiome
host-microbe interactions
phage-host interactions
temperate phage

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Online availability

10.1016/j.celrep.2020.108142

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title = "Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe",

abstract = "Integrative phages can have myriad effects on bacterial hosts. Campbell et al. find that integration of Bacteroides phage BV01 into Bacteroides vulgatus disrupts expression of TspO, reducing bile acid deconjugation. This is predicted to affect gut colonization and interactions with the human host. BV01 belongs to the Salyersviridae family.",

keywords = "Bacteroides, bacteriophage, bile acids, gut microbiome, host-microbe interactions, phage-host interactions, temperate phage",

author = "Campbell, {Danielle E.} and Ly, {Lindsey K.} and Ridlon, {Jason M.} and Ansel Hsiao and Whitaker, {Rachel J.} and Degnan, {Patrick H.}",

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doi = "10.1016/j.celrep.2020.108142",

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AU - Campbell, Danielle E.

AU - Ly, Lindsey K.

AU - Ridlon, Jason M.

AU - Hsiao, Ansel

AU - Whitaker, Rachel J.

AU - Degnan, Patrick H.

PY - 2020/9/15

Y1 - 2020/9/15

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AB - Integrative phages can have myriad effects on bacterial hosts. Campbell et al. find that integration of Bacteroides phage BV01 into Bacteroides vulgatus disrupts expression of TspO, reducing bile acid deconjugation. This is predicted to affect gut colonization and interactions with the human host. BV01 belongs to the Salyersviridae family.

KW - Bacteroides

KW - bacteriophage

KW - bile acids

KW - gut microbiome

KW - host-microbe interactions

KW - phage-host interactions

KW - temperate phage

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Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe

Abstract

Keywords

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