TY - JOUR
T1 - Infection by bacteriophage lambda
T2 - an evolving paradigm for cellular individuality
AU - Golding, Ido
N1 - Funding Information:
I am grateful to Seth Coleman, Thu Vu Phuc Nguyen and Anna Sokac for valuable comments. Work in the Golding lab is supported by grants from the National Institutes of Health ( R01 GM082837 ), the National Science Foundation ( PHY 1147498 , PHY 1430124 and PHY 1427654 ), the Welch Foundation ( Q-1759 ) and the John S. Dunn Foundation (Collaborative Research Award). I gratefully acknowledge the computing resources provided by the CIBR Center of Baylor College of Medicine.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Since the earliest days of molecular biology, bacteriophage lambda has served to illuminate cellular function. Among its many roles, lambda infection is a paradigm for phenotypic heterogeneity among genetically identical cells. Early studies attributed this cellular individuality to random biochemical fluctuations, or ‘noise’. More recently, however, attention has turned to the role played by deterministic hidden variables in driving single-cell behavior. Here, I briefly describe how studies in lambda are driving the shift in our understanding of cellular heterogeneity, allowing us to better appreciate the precision at which cells function.
AB - Since the earliest days of molecular biology, bacteriophage lambda has served to illuminate cellular function. Among its many roles, lambda infection is a paradigm for phenotypic heterogeneity among genetically identical cells. Early studies attributed this cellular individuality to random biochemical fluctuations, or ‘noise’. More recently, however, attention has turned to the role played by deterministic hidden variables in driving single-cell behavior. Here, I briefly describe how studies in lambda are driving the shift in our understanding of cellular heterogeneity, allowing us to better appreciate the precision at which cells function.
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U2 - 10.1016/j.mib.2017.09.014
DO - 10.1016/j.mib.2017.09.014
M3 - Review article
C2 - 29107897
AN - SCOPUS:85032927159
SN - 1369-5274
VL - 43
SP - 9
EP - 13
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -