Infant Development and Pre- and Post-partum Depression in Rural South African HIV-Infected Women

Violeta J. Rodriguez, Gladys Matseke, Ryan Cook, Seanna Bellinger, Stephen M. Weiss, Maria L. Alcaide, Karl Peltzer, Doyle Patton, Maria Lopez, Deborah L. Jones

Research output: Contribution to journalArticlepeer-review


HIV-exposed infants born to depressed women may be at risk for adverse developmental outcomes. Half of HIV-infected women in rural South Africa (SA) may suffer from pregnancy-related depression. This pilot study examined the impact of depression in HIV-infected women in rural SA on infant development. Mother-infant dyads (N = 69) were recruited in rural SA. Demographics, HIV disclosure, depression, male involvement, and alcohol use at baseline (18.35 ± 5.47 weeks gestation) were assessed. Male involvement, depression, infant HIV serostatus and development were assessed 12 months postnatally. Half of the women (age = 29 ± 5) reported depression prenatally and one-third reported depression postnatally. In multivariable logistic regression, not cohabiting with their male partner, nondisclosure of HIV status, and postnatal depression predicted cognitive delay; decreased prenatal male involvement predicted delayed gross motor development (ps < 0.05). Assessing pregnancy-related depression among HIV-infected women and infant development and increasing male involvement may reduce negative developmental outcomes among HIV-exposed or infected infants.

Original languageEnglish (US)
Pages (from-to)1766-1774
Number of pages9
JournalAIDS and Behavior
Issue number6
StatePublished - Jun 1 2018
Externally publishedYes


  • Depression
  • HIV
  • Infant development
  • South Africa
  • Women

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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