Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity

Antonio M. Chiarelli, Mark A. Fletcher, Chin Hong Tan, Kathy A. Low, Edward L. Maclin, Benjamin Zimmerman, Tania Kong, Alexander Gorsuch, Gabriele Gratton, Monica Fabiani

Research output: Contribution to journalArticle

Abstract

Aging is often accompanied by changes in brain anatomy and cerebrovascular health. However, the specific relationship between declines in regional cortical volumes and loss of cerebral arterial elasticity is less clear, as only global or very localized estimates of cerebrovascular health have been available. Here we employed a novel tomographic optical method (pulse-DOT) to derive local estimates of cerebral arterial elasticity and compared regional volumetric estimates (obtained with FreeSurfer) with optical arterial elasticity estimates from the same regions in 47 healthy adults (aged 18–75). Between-subject analyses revealed a global correlation between cortical volume and cortical arterial elasticity, which was a significant mediator of the association between age and cortical volume. Crucially, a novel within-subject analysis highlighted the spatial association between regional variability in cortical volumes and arterial elasticity in the same regions. This association strengthened with age. Gains in the predictability of cortical volumes from arterial elasticity data were obtained by sharpening the resolution up to individual cortical regions. These results indicate that some of the variance of sub-clinical age-related brain atrophy is associated with differences in the status of cerebral arteries, and can help explain the unique patterns of brain atrophy found within each individual.

Original languageEnglish (US)
Pages (from-to)199-213
Number of pages15
JournalNeuroImage
Volume162
DOIs
StatePublished - Nov 15 2017

Fingerprint

Elasticity
Individuality
Atrophy
Brain
Spatial Analysis
Cerebral Arteries
Health
Pulse
Anatomy

Keywords

  • Aging
  • Cerebrovascular health
  • Diffuse optical tomography (DOT)
  • FreeSurfer
  • Optical arterial pulse measures (pulse-DOT)
  • Structural magnetic resonance imaging (sMRI)

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity. / Chiarelli, Antonio M.; Fletcher, Mark A.; Tan, Chin Hong; Low, Kathy A.; Maclin, Edward L.; Zimmerman, Benjamin; Kong, Tania; Gorsuch, Alexander; Gratton, Gabriele; Fabiani, Monica.

In: NeuroImage, Vol. 162, 15.11.2017, p. 199-213.

Research output: Contribution to journalArticle

Chiarelli, Antonio M. ; Fletcher, Mark A. ; Tan, Chin Hong ; Low, Kathy A. ; Maclin, Edward L. ; Zimmerman, Benjamin ; Kong, Tania ; Gorsuch, Alexander ; Gratton, Gabriele ; Fabiani, Monica. / Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity. In: NeuroImage. 2017 ; Vol. 162. pp. 199-213.
@article{4d51c43c0253470796159f326323f13f,
title = "Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity",
abstract = "Aging is often accompanied by changes in brain anatomy and cerebrovascular health. However, the specific relationship between declines in regional cortical volumes and loss of cerebral arterial elasticity is less clear, as only global or very localized estimates of cerebrovascular health have been available. Here we employed a novel tomographic optical method (pulse-DOT) to derive local estimates of cerebral arterial elasticity and compared regional volumetric estimates (obtained with FreeSurfer) with optical arterial elasticity estimates from the same regions in 47 healthy adults (aged 18–75). Between-subject analyses revealed a global correlation between cortical volume and cortical arterial elasticity, which was a significant mediator of the association between age and cortical volume. Crucially, a novel within-subject analysis highlighted the spatial association between regional variability in cortical volumes and arterial elasticity in the same regions. This association strengthened with age. Gains in the predictability of cortical volumes from arterial elasticity data were obtained by sharpening the resolution up to individual cortical regions. These results indicate that some of the variance of sub-clinical age-related brain atrophy is associated with differences in the status of cerebral arteries, and can help explain the unique patterns of brain atrophy found within each individual.",
keywords = "Aging, Cerebrovascular health, Diffuse optical tomography (DOT), FreeSurfer, Optical arterial pulse measures (pulse-DOT), Structural magnetic resonance imaging (sMRI)",
author = "Chiarelli, {Antonio M.} and Fletcher, {Mark A.} and Tan, {Chin Hong} and Low, {Kathy A.} and Maclin, {Edward L.} and Benjamin Zimmerman and Tania Kong and Alexander Gorsuch and Gabriele Gratton and Monica Fabiani",
year = "2017",
month = "11",
day = "15",
doi = "10.1016/j.neuroimage.2017.08.064",
language = "English (US)",
volume = "162",
pages = "199--213",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Individual differences in regional cortical volumes across the life span are associated with regional optical measures of arterial elasticity

AU - Chiarelli, Antonio M.

AU - Fletcher, Mark A.

AU - Tan, Chin Hong

AU - Low, Kathy A.

AU - Maclin, Edward L.

AU - Zimmerman, Benjamin

AU - Kong, Tania

AU - Gorsuch, Alexander

AU - Gratton, Gabriele

AU - Fabiani, Monica

PY - 2017/11/15

Y1 - 2017/11/15

N2 - Aging is often accompanied by changes in brain anatomy and cerebrovascular health. However, the specific relationship between declines in regional cortical volumes and loss of cerebral arterial elasticity is less clear, as only global or very localized estimates of cerebrovascular health have been available. Here we employed a novel tomographic optical method (pulse-DOT) to derive local estimates of cerebral arterial elasticity and compared regional volumetric estimates (obtained with FreeSurfer) with optical arterial elasticity estimates from the same regions in 47 healthy adults (aged 18–75). Between-subject analyses revealed a global correlation between cortical volume and cortical arterial elasticity, which was a significant mediator of the association between age and cortical volume. Crucially, a novel within-subject analysis highlighted the spatial association between regional variability in cortical volumes and arterial elasticity in the same regions. This association strengthened with age. Gains in the predictability of cortical volumes from arterial elasticity data were obtained by sharpening the resolution up to individual cortical regions. These results indicate that some of the variance of sub-clinical age-related brain atrophy is associated with differences in the status of cerebral arteries, and can help explain the unique patterns of brain atrophy found within each individual.

AB - Aging is often accompanied by changes in brain anatomy and cerebrovascular health. However, the specific relationship between declines in regional cortical volumes and loss of cerebral arterial elasticity is less clear, as only global or very localized estimates of cerebrovascular health have been available. Here we employed a novel tomographic optical method (pulse-DOT) to derive local estimates of cerebral arterial elasticity and compared regional volumetric estimates (obtained with FreeSurfer) with optical arterial elasticity estimates from the same regions in 47 healthy adults (aged 18–75). Between-subject analyses revealed a global correlation between cortical volume and cortical arterial elasticity, which was a significant mediator of the association between age and cortical volume. Crucially, a novel within-subject analysis highlighted the spatial association between regional variability in cortical volumes and arterial elasticity in the same regions. This association strengthened with age. Gains in the predictability of cortical volumes from arterial elasticity data were obtained by sharpening the resolution up to individual cortical regions. These results indicate that some of the variance of sub-clinical age-related brain atrophy is associated with differences in the status of cerebral arteries, and can help explain the unique patterns of brain atrophy found within each individual.

KW - Aging

KW - Cerebrovascular health

KW - Diffuse optical tomography (DOT)

KW - FreeSurfer

KW - Optical arterial pulse measures (pulse-DOT)

KW - Structural magnetic resonance imaging (sMRI)

UR - http://www.scopus.com/inward/record.url?scp=85029079464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029079464&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2017.08.064

DO - 10.1016/j.neuroimage.2017.08.064

M3 - Article

C2 - 28866349

AN - SCOPUS:85029079464

VL - 162

SP - 199

EP - 213

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -