Independent control over size, valence, and elemental composition in the synthesis of DNA-nanoparticle conjugates

Yugang Bai, Hang Xing, Yunhao Bai, Li Huey Tan, Kevin Hwang, Ji Li, Yi Lu, Steven C. Zimmerman

Research output: Contribution to journalArticle

Abstract

DNA-nanoparticle conjugates have found widespread use in sensing, imaging, and as components of devices. However, their synthesis remains relatively complicated and empirically based, often requiring specialized protocols for conjugates of different size, valence, and elemental composition. Here we report a novel, bottom-up approach for the synthesis of DNA-nanoparticle conjugates, based on ring-opening metathesis polymerization (ROMP), intramolecular crosslinking, and template synthesis. Using size, valence, and elemental composition as three independent synthetic parameters, various conjugates can be obtained using a facile and universal procedure. Examples are given to show the usefulness of these conjugates as sensing probes, building blocks for self-assembly, and as model particles for structure-property relationship studies.

Original languageEnglish (US)
Pages (from-to)1564-1572
Number of pages9
JournalChemical Science
Volume11
Issue number6
DOIs
StatePublished - Feb 14 2020

ASJC Scopus subject areas

  • Chemistry(all)

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